Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment

PURPOSE: To present a 3-year-old female patient with a non-familial, isolated, unilateral case of left corneal anesthesia with MRI-confirmed congenital left trigeminal nerve aplasia. OBSERVATIONS: A corneal epithelial defect was noted in the left eye after an 8-week trial of recombinant human nerve...

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Autores principales: Kamal, Sarah M., Riccobono, Kellen, Kwok, Alan, Edmond, Jane C., Pflugfelder, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568187/
https://www.ncbi.nlm.nih.gov/pubmed/33094195
http://dx.doi.org/10.1016/j.ajoc.2020.100854
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author Kamal, Sarah M.
Riccobono, Kellen
Kwok, Alan
Edmond, Jane C.
Pflugfelder, Stephen C.
author_facet Kamal, Sarah M.
Riccobono, Kellen
Kwok, Alan
Edmond, Jane C.
Pflugfelder, Stephen C.
author_sort Kamal, Sarah M.
collection PubMed
description PURPOSE: To present a 3-year-old female patient with a non-familial, isolated, unilateral case of left corneal anesthesia with MRI-confirmed congenital left trigeminal nerve aplasia. OBSERVATIONS: A corneal epithelial defect was noted in the left eye after an 8-week trial of recombinant human nerve growth factor. Subsequent evaluation and fitting of a PROSE (prosthetic replacement of the ocular surface ecosystem) lens led to healing of the corneal epithelium and visual acuity improvement from 20/300 to 20/70. CONCLUSIONS AND IMPORTANCE: A scleral lens may be a possible treatment for those with neurotrophic keratitis in which a trial of topical lubrication and human nerve growth factor has not been effective.
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spelling pubmed-75681872020-10-21 Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment Kamal, Sarah M. Riccobono, Kellen Kwok, Alan Edmond, Jane C. Pflugfelder, Stephen C. Am J Ophthalmol Case Rep Case Report PURPOSE: To present a 3-year-old female patient with a non-familial, isolated, unilateral case of left corneal anesthesia with MRI-confirmed congenital left trigeminal nerve aplasia. OBSERVATIONS: A corneal epithelial defect was noted in the left eye after an 8-week trial of recombinant human nerve growth factor. Subsequent evaluation and fitting of a PROSE (prosthetic replacement of the ocular surface ecosystem) lens led to healing of the corneal epithelium and visual acuity improvement from 20/300 to 20/70. CONCLUSIONS AND IMPORTANCE: A scleral lens may be a possible treatment for those with neurotrophic keratitis in which a trial of topical lubrication and human nerve growth factor has not been effective. Elsevier 2020-08-03 /pmc/articles/PMC7568187/ /pubmed/33094195 http://dx.doi.org/10.1016/j.ajoc.2020.100854 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kamal, Sarah M.
Riccobono, Kellen
Kwok, Alan
Edmond, Jane C.
Pflugfelder, Stephen C.
Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment
title Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment
title_full Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment
title_fullStr Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment
title_full_unstemmed Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment
title_short Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment
title_sort unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with prose (prosthetic replacement of the ocular surface ecosystem) treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568187/
https://www.ncbi.nlm.nih.gov/pubmed/33094195
http://dx.doi.org/10.1016/j.ajoc.2020.100854
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