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Fusidic acid resistance through changes in the dynamics of the drug target

Antibiotic resistance in clinically important bacteria can be mediated by target protection mechanisms, whereby a protein binds to the drug target and protects it from the inhibitory effects of the antibiotic. The most prevalent source of clinical resistance to the antibiotic fusidic acid (FA) is ex...

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Detalles Bibliográficos
Autores principales: Tomlinson, Jennifer H., Kalverda, Arnout P., Calabrese, Antonio N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568287/
https://www.ncbi.nlm.nih.gov/pubmed/32999060
http://dx.doi.org/10.1073/pnas.2008577117