Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upo...

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Detalles Bibliográficos
Autores principales: Yang, Jing, Huang, Xinmei, Liu, Yuzhuo, Zhao, Dongmin, Han, Kaikai, Zhang, Lijiao, Li, Yin, Liu, Qingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568386/
https://www.ncbi.nlm.nih.gov/pubmed/33069243
http://dx.doi.org/10.1186/s13567-020-00856-z
Descripción
Sumario:MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.

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