Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upo...

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Autores principales: Yang, Jing, Huang, Xinmei, Liu, Yuzhuo, Zhao, Dongmin, Han, Kaikai, Zhang, Lijiao, Li, Yin, Liu, Qingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568386/
https://www.ncbi.nlm.nih.gov/pubmed/33069243
http://dx.doi.org/10.1186/s13567-020-00856-z
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author Yang, Jing
Huang, Xinmei
Liu, Yuzhuo
Zhao, Dongmin
Han, Kaikai
Zhang, Lijiao
Li, Yin
Liu, Qingtao
author_facet Yang, Jing
Huang, Xinmei
Liu, Yuzhuo
Zhao, Dongmin
Han, Kaikai
Zhang, Lijiao
Li, Yin
Liu, Qingtao
author_sort Yang, Jing
collection PubMed
description MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
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spelling pubmed-75683862020-10-20 Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection Yang, Jing Huang, Xinmei Liu, Yuzhuo Zhao, Dongmin Han, Kaikai Zhang, Lijiao Li, Yin Liu, Qingtao Vet Res Short Report MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response. BioMed Central 2020-10-17 2020 /pmc/articles/PMC7568386/ /pubmed/33069243 http://dx.doi.org/10.1186/s13567-020-00856-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Yang, Jing
Huang, Xinmei
Liu, Yuzhuo
Zhao, Dongmin
Han, Kaikai
Zhang, Lijiao
Li, Yin
Liu, Qingtao
Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
title Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
title_full Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
title_fullStr Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
title_full_unstemmed Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
title_short Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
title_sort analysis of the microrna expression profiles of chicken dendritic cells in response to h9n2 avian influenza virus infection
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568386/
https://www.ncbi.nlm.nih.gov/pubmed/33069243
http://dx.doi.org/10.1186/s13567-020-00856-z
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