Cargando…

Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)

OBJECTIVES: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. STUDY DESIGN: Using a cohort design, we identified term infants evaluated for EOS wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Polcwiartek, Laura Bech, Smith, P. Brian, Benjamin, Daniel K., Zimmerman, Kanecia, Love, Alycia, Tiu, Lance, Murray, Sylvia, Kang, Phillip, Ebbesen, Finn, Hagstrøm, Søren, Clark, Reese H., Greenberg, Rachel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568457/
https://www.ncbi.nlm.nih.gov/pubmed/33070153
http://dx.doi.org/10.1038/s41372-020-00860-3
_version_ 1783596522280058880
author Polcwiartek, Laura Bech
Smith, P. Brian
Benjamin, Daniel K.
Zimmerman, Kanecia
Love, Alycia
Tiu, Lance
Murray, Sylvia
Kang, Phillip
Ebbesen, Finn
Hagstrøm, Søren
Clark, Reese H.
Greenberg, Rachel G.
author_facet Polcwiartek, Laura Bech
Smith, P. Brian
Benjamin, Daniel K.
Zimmerman, Kanecia
Love, Alycia
Tiu, Lance
Murray, Sylvia
Kang, Phillip
Ebbesen, Finn
Hagstrøm, Søren
Clark, Reese H.
Greenberg, Rachel G.
author_sort Polcwiartek, Laura Bech
collection PubMed
description OBJECTIVES: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. STUDY DESIGN: Using a cohort design, we identified term infants evaluated for EOS with blood, cerebrospinal fluid, or urine cultures in 326 NICUs (2011–2016). Using multivariable logistic regression, we investigated the association between EOS and demographic characteristics. RESULTS: Of 142,410 infants, 1197 (0.8%) had EOS, most commonly caused by group B Streptococcus (GBS; 40.6%). Lower EOS risk was associated with low Apgar score, Cesarean delivery, small for gestational age, prenatal antibiotic exposure, and positive or unknown maternal GBS screening result. Increased risk was associated with prolonged rupture of membranes, maternal age <19 years, vasopressor treatment, and ventilator support. CONCLUSION(S): GBS was the most frequent cause of EOS. Early risk factor recognition may help daily management of term infants in NICUs.
format Online
Article
Text
id pubmed-7568457
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group US
record_format MEDLINE/PubMed
spelling pubmed-75684572020-10-19 Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) Polcwiartek, Laura Bech Smith, P. Brian Benjamin, Daniel K. Zimmerman, Kanecia Love, Alycia Tiu, Lance Murray, Sylvia Kang, Phillip Ebbesen, Finn Hagstrøm, Søren Clark, Reese H. Greenberg, Rachel G. J Perinatol Article OBJECTIVES: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. STUDY DESIGN: Using a cohort design, we identified term infants evaluated for EOS with blood, cerebrospinal fluid, or urine cultures in 326 NICUs (2011–2016). Using multivariable logistic regression, we investigated the association between EOS and demographic characteristics. RESULTS: Of 142,410 infants, 1197 (0.8%) had EOS, most commonly caused by group B Streptococcus (GBS; 40.6%). Lower EOS risk was associated with low Apgar score, Cesarean delivery, small for gestational age, prenatal antibiotic exposure, and positive or unknown maternal GBS screening result. Increased risk was associated with prolonged rupture of membranes, maternal age <19 years, vasopressor treatment, and ventilator support. CONCLUSION(S): GBS was the most frequent cause of EOS. Early risk factor recognition may help daily management of term infants in NICUs. Nature Publishing Group US 2020-10-17 2021 /pmc/articles/PMC7568457/ /pubmed/33070153 http://dx.doi.org/10.1038/s41372-020-00860-3 Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Polcwiartek, Laura Bech
Smith, P. Brian
Benjamin, Daniel K.
Zimmerman, Kanecia
Love, Alycia
Tiu, Lance
Murray, Sylvia
Kang, Phillip
Ebbesen, Finn
Hagstrøm, Søren
Clark, Reese H.
Greenberg, Rachel G.
Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
title Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
title_full Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
title_fullStr Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
title_full_unstemmed Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
title_short Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
title_sort early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568457/
https://www.ncbi.nlm.nih.gov/pubmed/33070153
http://dx.doi.org/10.1038/s41372-020-00860-3
work_keys_str_mv AT polcwiarteklaurabech earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT smithpbrian earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT benjamindanielk earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT zimmermankanecia earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT lovealycia earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT tiulance earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT murraysylvia earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT kangphillip earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT ebbesenfinn earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT hagstrømsøren earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT clarkreeseh earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016
AT greenbergrachelg earlyonsetsepsisinterminfantsadmittedtoneonatalintensivecareunits20112016