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Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)
OBJECTIVES: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. STUDY DESIGN: Using a cohort design, we identified term infants evaluated for EOS wi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568457/ https://www.ncbi.nlm.nih.gov/pubmed/33070153 http://dx.doi.org/10.1038/s41372-020-00860-3 |
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author | Polcwiartek, Laura Bech Smith, P. Brian Benjamin, Daniel K. Zimmerman, Kanecia Love, Alycia Tiu, Lance Murray, Sylvia Kang, Phillip Ebbesen, Finn Hagstrøm, Søren Clark, Reese H. Greenberg, Rachel G. |
author_facet | Polcwiartek, Laura Bech Smith, P. Brian Benjamin, Daniel K. Zimmerman, Kanecia Love, Alycia Tiu, Lance Murray, Sylvia Kang, Phillip Ebbesen, Finn Hagstrøm, Søren Clark, Reese H. Greenberg, Rachel G. |
author_sort | Polcwiartek, Laura Bech |
collection | PubMed |
description | OBJECTIVES: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. STUDY DESIGN: Using a cohort design, we identified term infants evaluated for EOS with blood, cerebrospinal fluid, or urine cultures in 326 NICUs (2011–2016). Using multivariable logistic regression, we investigated the association between EOS and demographic characteristics. RESULTS: Of 142,410 infants, 1197 (0.8%) had EOS, most commonly caused by group B Streptococcus (GBS; 40.6%). Lower EOS risk was associated with low Apgar score, Cesarean delivery, small for gestational age, prenatal antibiotic exposure, and positive or unknown maternal GBS screening result. Increased risk was associated with prolonged rupture of membranes, maternal age <19 years, vasopressor treatment, and ventilator support. CONCLUSION(S): GBS was the most frequent cause of EOS. Early risk factor recognition may help daily management of term infants in NICUs. |
format | Online Article Text |
id | pubmed-7568457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-75684572020-10-19 Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) Polcwiartek, Laura Bech Smith, P. Brian Benjamin, Daniel K. Zimmerman, Kanecia Love, Alycia Tiu, Lance Murray, Sylvia Kang, Phillip Ebbesen, Finn Hagstrøm, Søren Clark, Reese H. Greenberg, Rachel G. J Perinatol Article OBJECTIVES: Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. STUDY DESIGN: Using a cohort design, we identified term infants evaluated for EOS with blood, cerebrospinal fluid, or urine cultures in 326 NICUs (2011–2016). Using multivariable logistic regression, we investigated the association between EOS and demographic characteristics. RESULTS: Of 142,410 infants, 1197 (0.8%) had EOS, most commonly caused by group B Streptococcus (GBS; 40.6%). Lower EOS risk was associated with low Apgar score, Cesarean delivery, small for gestational age, prenatal antibiotic exposure, and positive or unknown maternal GBS screening result. Increased risk was associated with prolonged rupture of membranes, maternal age <19 years, vasopressor treatment, and ventilator support. CONCLUSION(S): GBS was the most frequent cause of EOS. Early risk factor recognition may help daily management of term infants in NICUs. Nature Publishing Group US 2020-10-17 2021 /pmc/articles/PMC7568457/ /pubmed/33070153 http://dx.doi.org/10.1038/s41372-020-00860-3 Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Polcwiartek, Laura Bech Smith, P. Brian Benjamin, Daniel K. Zimmerman, Kanecia Love, Alycia Tiu, Lance Murray, Sylvia Kang, Phillip Ebbesen, Finn Hagstrøm, Søren Clark, Reese H. Greenberg, Rachel G. Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) |
title | Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) |
title_full | Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) |
title_fullStr | Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) |
title_full_unstemmed | Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) |
title_short | Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) |
title_sort | early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568457/ https://www.ncbi.nlm.nih.gov/pubmed/33070153 http://dx.doi.org/10.1038/s41372-020-00860-3 |
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