Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections

Placental macrophages are a heterogenous population of immune cells present throughout pregnancy. They are essential for maintenance of the homeostatic placenta environment and host defense against infections. The characterization of placental macrophages as well as their activation have been limite...

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Autores principales: Mezouar, Soraya, Katsogiannou, Maria, Ben Amara, Amira, Bretelle, Florence, Mege, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568513/
https://www.ncbi.nlm.nih.gov/pubmed/33120051
http://dx.doi.org/10.1016/j.placenta.2020.10.017
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author Mezouar, Soraya
Katsogiannou, Maria
Ben Amara, Amira
Bretelle, Florence
Mege, Jean-Louis
author_facet Mezouar, Soraya
Katsogiannou, Maria
Ben Amara, Amira
Bretelle, Florence
Mege, Jean-Louis
author_sort Mezouar, Soraya
collection PubMed
description Placental macrophages are a heterogenous population of immune cells present throughout pregnancy. They are essential for maintenance of the homeostatic placenta environment and host defense against infections. The characterization of placental macrophages as well as their activation have been limited for a long time by the lack of convenient tools. The emergence of unbiased methods makes it possible to reappraise the study of placental macrophages. In this review, we discuss the diversity and the functions of placental macrophages to better understand their dysfunctions during placental infections.
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spelling pubmed-75685132020-10-19 Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections Mezouar, Soraya Katsogiannou, Maria Ben Amara, Amira Bretelle, Florence Mege, Jean-Louis Placenta Article Placental macrophages are a heterogenous population of immune cells present throughout pregnancy. They are essential for maintenance of the homeostatic placenta environment and host defense against infections. The characterization of placental macrophages as well as their activation have been limited for a long time by the lack of convenient tools. The emergence of unbiased methods makes it possible to reappraise the study of placental macrophages. In this review, we discuss the diversity and the functions of placental macrophages to better understand their dysfunctions during placental infections. Elsevier Ltd. 2021-01-01 2020-10-17 /pmc/articles/PMC7568513/ /pubmed/33120051 http://dx.doi.org/10.1016/j.placenta.2020.10.017 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mezouar, Soraya
Katsogiannou, Maria
Ben Amara, Amira
Bretelle, Florence
Mege, Jean-Louis
Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections
title Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections
title_full Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections
title_fullStr Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections
title_full_unstemmed Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections
title_short Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections
title_sort placental macrophages: origin, heterogeneity, function and role in pregnancy-associated infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568513/
https://www.ncbi.nlm.nih.gov/pubmed/33120051
http://dx.doi.org/10.1016/j.placenta.2020.10.017
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AT bretelleflorence placentalmacrophagesoriginheterogeneityfunctionandroleinpregnancyassociatedinfections
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