A high-stringency blueprint of the human proteome

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established...

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Autores principales: Adhikari, Subash, Nice, Edouard C., Deutsch, Eric W., Lane, Lydie, Omenn, Gilbert S., Pennington, Stephen R., Paik, Young-Ki, Overall, Christopher M., Corrales, Fernando J., Cristea, Ileana M., Van Eyk, Jennifer E., Uhlén, Mathias, Lindskog, Cecilia, Chan, Daniel W., Bairoch, Amos, Waddington, James C., Justice, Joshua L., LaBaer, Joshua, Rodriguez, Henry, He, Fuchu, Kostrzewa, Markus, Ping, Peipei, Gundry, Rebekah L., Stewart, Peter, Srivastava, Sanjeeva, Srivastava, Sudhir, Nogueira, Fabio C. S., Domont, Gilberto B., Vandenbrouck, Yves, Lam, Maggie P. Y., Wennersten, Sara, Vizcaino, Juan Antonio, Wilkins, Marc, Schwenk, Jochen M., Lundberg, Emma, Bandeira, Nuno, Marko-Varga, Gyorgy, Weintraub, Susan T., Pineau, Charles, Kusebauch, Ulrike, Moritz, Robert L., Ahn, Seong Beom, Palmblad, Magnus, Snyder, Michael P., Aebersold, Ruedi, Baker, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568584/
https://www.ncbi.nlm.nih.gov/pubmed/33067450
http://dx.doi.org/10.1038/s41467-020-19045-9
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author Adhikari, Subash
Nice, Edouard C.
Deutsch, Eric W.
Lane, Lydie
Omenn, Gilbert S.
Pennington, Stephen R.
Paik, Young-Ki
Overall, Christopher M.
Corrales, Fernando J.
Cristea, Ileana M.
Van Eyk, Jennifer E.
Uhlén, Mathias
Lindskog, Cecilia
Chan, Daniel W.
Bairoch, Amos
Waddington, James C.
Justice, Joshua L.
LaBaer, Joshua
Rodriguez, Henry
He, Fuchu
Kostrzewa, Markus
Ping, Peipei
Gundry, Rebekah L.
Stewart, Peter
Srivastava, Sanjeeva
Srivastava, Sudhir
Nogueira, Fabio C. S.
Domont, Gilberto B.
Vandenbrouck, Yves
Lam, Maggie P. Y.
Wennersten, Sara
Vizcaino, Juan Antonio
Wilkins, Marc
Schwenk, Jochen M.
Lundberg, Emma
Bandeira, Nuno
Marko-Varga, Gyorgy
Weintraub, Susan T.
Pineau, Charles
Kusebauch, Ulrike
Moritz, Robert L.
Ahn, Seong Beom
Palmblad, Magnus
Snyder, Michael P.
Aebersold, Ruedi
Baker, Mark S.
author_facet Adhikari, Subash
Nice, Edouard C.
Deutsch, Eric W.
Lane, Lydie
Omenn, Gilbert S.
Pennington, Stephen R.
Paik, Young-Ki
Overall, Christopher M.
Corrales, Fernando J.
Cristea, Ileana M.
Van Eyk, Jennifer E.
Uhlén, Mathias
Lindskog, Cecilia
Chan, Daniel W.
Bairoch, Amos
Waddington, James C.
Justice, Joshua L.
LaBaer, Joshua
Rodriguez, Henry
He, Fuchu
Kostrzewa, Markus
Ping, Peipei
Gundry, Rebekah L.
Stewart, Peter
Srivastava, Sanjeeva
Srivastava, Sudhir
Nogueira, Fabio C. S.
Domont, Gilberto B.
Vandenbrouck, Yves
Lam, Maggie P. Y.
Wennersten, Sara
Vizcaino, Juan Antonio
Wilkins, Marc
Schwenk, Jochen M.
Lundberg, Emma
Bandeira, Nuno
Marko-Varga, Gyorgy
Weintraub, Susan T.
Pineau, Charles
Kusebauch, Ulrike
Moritz, Robert L.
Ahn, Seong Beom
Palmblad, Magnus
Snyder, Michael P.
Aebersold, Ruedi
Baker, Mark S.
author_sort Adhikari, Subash
collection PubMed
description The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
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spelling pubmed-75685842020-10-21 A high-stringency blueprint of the human proteome Adhikari, Subash Nice, Edouard C. Deutsch, Eric W. Lane, Lydie Omenn, Gilbert S. Pennington, Stephen R. Paik, Young-Ki Overall, Christopher M. Corrales, Fernando J. Cristea, Ileana M. Van Eyk, Jennifer E. Uhlén, Mathias Lindskog, Cecilia Chan, Daniel W. Bairoch, Amos Waddington, James C. Justice, Joshua L. LaBaer, Joshua Rodriguez, Henry He, Fuchu Kostrzewa, Markus Ping, Peipei Gundry, Rebekah L. Stewart, Peter Srivastava, Sanjeeva Srivastava, Sudhir Nogueira, Fabio C. S. Domont, Gilberto B. Vandenbrouck, Yves Lam, Maggie P. Y. Wennersten, Sara Vizcaino, Juan Antonio Wilkins, Marc Schwenk, Jochen M. Lundberg, Emma Bandeira, Nuno Marko-Varga, Gyorgy Weintraub, Susan T. Pineau, Charles Kusebauch, Ulrike Moritz, Robert L. Ahn, Seong Beom Palmblad, Magnus Snyder, Michael P. Aebersold, Ruedi Baker, Mark S. Nat Commun Perspective The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases. Nature Publishing Group UK 2020-10-16 /pmc/articles/PMC7568584/ /pubmed/33067450 http://dx.doi.org/10.1038/s41467-020-19045-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Adhikari, Subash
Nice, Edouard C.
Deutsch, Eric W.
Lane, Lydie
Omenn, Gilbert S.
Pennington, Stephen R.
Paik, Young-Ki
Overall, Christopher M.
Corrales, Fernando J.
Cristea, Ileana M.
Van Eyk, Jennifer E.
Uhlén, Mathias
Lindskog, Cecilia
Chan, Daniel W.
Bairoch, Amos
Waddington, James C.
Justice, Joshua L.
LaBaer, Joshua
Rodriguez, Henry
He, Fuchu
Kostrzewa, Markus
Ping, Peipei
Gundry, Rebekah L.
Stewart, Peter
Srivastava, Sanjeeva
Srivastava, Sudhir
Nogueira, Fabio C. S.
Domont, Gilberto B.
Vandenbrouck, Yves
Lam, Maggie P. Y.
Wennersten, Sara
Vizcaino, Juan Antonio
Wilkins, Marc
Schwenk, Jochen M.
Lundberg, Emma
Bandeira, Nuno
Marko-Varga, Gyorgy
Weintraub, Susan T.
Pineau, Charles
Kusebauch, Ulrike
Moritz, Robert L.
Ahn, Seong Beom
Palmblad, Magnus
Snyder, Michael P.
Aebersold, Ruedi
Baker, Mark S.
A high-stringency blueprint of the human proteome
title A high-stringency blueprint of the human proteome
title_full A high-stringency blueprint of the human proteome
title_fullStr A high-stringency blueprint of the human proteome
title_full_unstemmed A high-stringency blueprint of the human proteome
title_short A high-stringency blueprint of the human proteome
title_sort high-stringency blueprint of the human proteome
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568584/
https://www.ncbi.nlm.nih.gov/pubmed/33067450
http://dx.doi.org/10.1038/s41467-020-19045-9
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