Establishment of a Controlled Human Infection Model with a Lyophilized Strain of Shigella sonnei 53G

Controlled human infection models (CHIMs) are useful for vaccine development. To improve on existing models, we developed a CHIM using a lyophilized preparation of Shigella sonnei strain 53G produced using current good manufacturing practice (cGMP). Healthy adults were enrolled in an open-label dose...

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Detalles Bibliográficos
Autores principales: Frenck, Robert W., Dickey, Michelle, Suvarnapunya, Akamol E., Chandrasekaran, Lakshmi, Kaminski, Robert W., Clarkson, Kristen A., McNeal, Monica, Lynen, Amanda, Parker, Susan, Hoeper, Amy, Mani, Sachin, Fix, Alan, Maier, Nicole, Venkatesan, Malabi M., Porter, Chad K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568646/
https://www.ncbi.nlm.nih.gov/pubmed/32968005
http://dx.doi.org/10.1128/mSphere.00416-20

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