Cargando…
A Trypanosoma brucei ORFeome-Based Gain-of-Function Library Identifies Genes That Promote Survival during Melarsoprol Treatment
Trypanosoma brucei is an early branching protozoan parasite that causes human and animal African trypanosomiasis. Forward genetics approaches are powerful tools for uncovering novel aspects of trypanosomatid biology, pathogenesis, and therapeutic approaches against trypanosomiasis. Here, we have gen...
Autores principales: | Carter, McKenzie, Gomez, Stephanie, Gritz, Sam, Larson, Stephen, Silva-Herzog, Eugenia, Kim, Hee-Sook, Schulz, Danae, Hovel-Miner, Galadriel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568655/ https://www.ncbi.nlm.nih.gov/pubmed/33028684 http://dx.doi.org/10.1128/mSphere.00769-20 |
Ejemplares similares
-
Effects of trypanocidal drugs on DNA synthesis: new insights into melarsoprol growth inhibition
por: Larson, Stephen, et al.
Publicado: (2021) -
Telomere Length Affects the Frequency and Mechanism of Antigenic Variation in Trypanosoma brucei
por: Hovel-Miner, Galadriel A., et al.
Publicado: (2012) -
A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive
por: Hovel-Miner, Galadriel, et al.
Publicado: (2016) -
Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
por: Graf, Fabrice E., et al.
Publicado: (2013) -
Melarsoprol Sensitivity Profile of Trypanosoma brucei gambiense Isolates from Cured and Relapsed Sleeping Sickness Patients from the Democratic Republic of the Congo
por: Pyana Pati, Patient, et al.
Publicado: (2014)