Cargando…

Phase I trial evaluating safety and efficacy of intratumorally administered inflammatory allogeneic dendritic cells (ilixadencel) in advanced gastrointestinal stromal tumors

BACKGROUND: The majority of patients with advanced gastrointestinal stromal tumor (GIST) develop resistance to imatinib, and subsequent treatments have limited efficacy. Ilixadencel (allogeneic inflammatory dendritic cells) is a cell-based immune primer injected intratumorally that previously has be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fröbom, Robin, Berglund, Erik, Berglund, David, Nilsson, Inga-Lena, Åhlén, Jan, von Sivers, Karin, Linder-Stragliotto, Christina, Suenaert, Peter, Karlsson-Parra, Alex, Bränström, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568699/ https://www.ncbi.nlm.nih.gov/pubmed/32535637 http://dx.doi.org/10.1007/s00262-020-02625-5

Ejemplares similares

Ilixadencel – an Allogeneic Cell-Based Anticancer Immune Primer for Intratumoral Administration
por: Karlsson-Parra, Alex, et al.
Publicado: (2018)

Phase 1 Trial With the Cell-Based Immune Primer Ilixadencel, Alone, and Combined With Sorafenib, in Advanced Hepatocellular Carcinoma
por: Rizell, Magnus, et al.
Publicado: (2019)

Wide Surgical Margin Improves the Outcome for Patients with Gastrointestinal Stromal Tumors (GISTs)
por: Åhlén, Jan, et al.
Publicado: (2018)

The role of neoadjuvant imatinib in gastrointestinal stromal tumor patients: 20 years of experience from a tertial referral center
por: Renberg, Sara, et al.
Publicado: (2022)

Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study
por: Lindskog, Magnus, et al.
Publicado: (2022)

Polyvinyl Alcohol Carbazate as a Polymer-Based Antitumoral Agent
por: Sellberg, Felix, et al.
Publicado: (2021)

Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties
por: Bränström, Robert, et al.
Publicado: (2022)

microRNA expression signatures of gastrointestinal stromal tumours: associations with imatinib resistance and patient outcome
por: Akçakaya, P, et al.
Publicado: (2014)

Intratumorally injected pro-inflammatory allogeneic dendritic cells as immune enhancers: a first-in-human study in unfavourable risk patients with metastatic renal cell carcinoma
por: Laurell, Anna, et al.
Publicado: (2017)

Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response
por: Jin, Chuan, et al.
Publicado: (2022)

Cross‐matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting
por: Rowland, Aileen L., et al.
Publicado: (2020)

Long-term survival in unfavourable-risk mRCC patients after intratumoral administration of a cell-based allogeneic vaccine
por: Karlsson-Parra, Alex, et al.
Publicado: (2015)

Sarcoma of the breast: breast cancer history as etiologic and prognostic factor—A population-based case–control study
por: Karlsson, Fredrik, et al.
Publicado: (2020)

Intratumoral expression of FoxP3-positive regulatory T-cells in T-cell lymphoma: no correlation with survival
por: Lundberg, Josefine, et al.
Publicado: (2019)

Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment
por: Ali, Arwa, et al.
Publicado: (2023)

Biological effects of hydrogen peroxide administered intratumorally with or without irradiation in murine tumors
por: Takaoka, Taiki, et al.
Publicado: (2017)

Effects of Surface Protein Adsorption on the Distribution and Retention of Intratumorally Administered Gold Nanoparticles
por: Terracciano, Rossana, et al.
Publicado: (2021)

Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes
por: Chang, Hsuan-Ping, et al.
Publicado: (2023)

Allogeneic chondrogenically differentiated human bone marrow stromal cells do not induce dendritic cell maturation
por: Kiernan, C.H., et al.
Publicado: (2018)

The Prognostic Role of Intratumoral Stromal Content in Lobular Breast Cancer
por: Forsare, Carina, et al.
Publicado: (2022)

Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors
por: Albershardt, Tina C., et al.
Publicado: (2020)

Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells
por: Berglund, Alix K., et al.
Publicado: (2017)

A "prime-pull" immunotherapy approach using a lentiviral vector and intratumoral TLR4 agonist redirects cytotoxic T cells
por: Albershardt, Tina C, et al.
Publicado: (2014)

Intratumoral injections of G100 (synthetic TLR4 agonist) increase trafficking of lentiviral vector-induced antigen-specific CD8 T cells to the tumor microenvironment
por: Albershardt, Tina C, et al.
Publicado: (2015)

Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells
por: Raychaudhuri, Deblina, et al.
Publicado: (2019)

Infiltration by Intratumor and Stromal CD8 and CD68 in Cervical Cancer
por: Dimitrova, Polina, et al.
Publicado: (2023)

Allogeneic major histocompatibility complex‐mismatched equine bone marrow‐derived mesenchymal stem cells are targeted for death by cytotoxic anti‐major histocompatibility complex antibodies
por: Berglund, A.K., et al.
Publicado: (2016)

A retrospective study of SBRT of metastases in patients with primary sarcoma
por: Stragliotto, Christina Linder, et al.
Publicado: (2012)

Hyaluronate-Thiol Passivation Enhances Gold Nanoparticle Peritumoral Distribution When Administered Intratumorally in Lung Cancer
por: Terracciano, Rossana, et al.
Publicado: (2021)

Response to Intravenous Allogeneic Equine Cord Blood-Derived Mesenchymal Stromal Cells Administered from Chilled or Frozen State in Serum and Protein-Free Media
por: Williams, Lynn B., et al.
Publicado: (2016)

Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity
por: Wang, Yufeng, et al.
Publicado: (2021)

High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer
por: Wang, Tingting, et al.
Publicado: (2016)

Therapeutic Drug Monitoring of Orally Administered Letermovir Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplant Recipients
por: Royston, Léna, et al.
Publicado: (2022)

Combined Treatment of an Intratumoral Injection of Dendritic Cells and Systemic Chemotherapy (Paclitaxel) for Murine Fibrosarcoma
por: Choi, Gwang-Seong, et al.
Publicado: (2005)

Combined Treatment of Murine Fibrosarcoma with Chemotherapy (Paclitaxel), Radiotherapy, and Intratumoral Injection of Dendritic Cells
por: Byun, Ji-Won, et al.
Publicado: (2014)

A gastrointestinal stromal tumor of stomach presenting with an intratumoral abscess: A case report
por: Ballati, Ahmed, et al.
Publicado: (2021)

Case report: Giant cystic ileal gastrointestinal stromal tumor with an atypical intratumoral abscess
por: Chen, Linguang, et al.
Publicado: (2023)

Immune response to allogeneic equine mesenchymal stromal cells
por: Kamm, J. Lacy, et al.
Publicado: (2021)

Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function
por: Anderson, Per, et al.
Publicado: (2017)

Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory
por: Leleux, Jardin A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rc2hva4d1mflig47o4n41538vp