The risk of cardiovascular complications in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing disease of unknown etiology involving gastrointestinal tract. IBD comprises two main entities: ulcerative colitis and Crohn’s disease. Several studies showed increased risk of cardiovascular complications in chronic inflammatory disorders, esp...

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Autores principales: Czubkowski, Piotr, Osiecki, Marcin, Szymańska, Edyta, Kierkuś, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568702/
https://www.ncbi.nlm.nih.gov/pubmed/32785793
http://dx.doi.org/10.1007/s10238-020-00639-y
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author Czubkowski, Piotr
Osiecki, Marcin
Szymańska, Edyta
Kierkuś, Jarosław
author_facet Czubkowski, Piotr
Osiecki, Marcin
Szymańska, Edyta
Kierkuś, Jarosław
author_sort Czubkowski, Piotr
collection PubMed
description Inflammatory bowel disease (IBD) is a chronic, relapsing disease of unknown etiology involving gastrointestinal tract. IBD comprises two main entities: ulcerative colitis and Crohn’s disease. Several studies showed increased risk of cardiovascular complications in chronic inflammatory disorders, especially during IBD relapses. Endothelium plays a role in physiologic regulation of vascular tone, cell adhesion, migration and resistance to thrombosis. Also, its dysfunction is associated with increased risk of atherosclerosis development. There are several potential links between chronic IBD-related inflammatory processes and the risk of cardiovascular disease, but insight into pathogenetic pathways remains unclear. We present the current concepts and review of adult and pediatric studies on the risk of CVD in IBD.
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spelling pubmed-75687022020-10-19 The risk of cardiovascular complications in inflammatory bowel disease Czubkowski, Piotr Osiecki, Marcin Szymańska, Edyta Kierkuś, Jarosław Clin Exp Med Review Article Inflammatory bowel disease (IBD) is a chronic, relapsing disease of unknown etiology involving gastrointestinal tract. IBD comprises two main entities: ulcerative colitis and Crohn’s disease. Several studies showed increased risk of cardiovascular complications in chronic inflammatory disorders, especially during IBD relapses. Endothelium plays a role in physiologic regulation of vascular tone, cell adhesion, migration and resistance to thrombosis. Also, its dysfunction is associated with increased risk of atherosclerosis development. There are several potential links between chronic IBD-related inflammatory processes and the risk of cardiovascular disease, but insight into pathogenetic pathways remains unclear. We present the current concepts and review of adult and pediatric studies on the risk of CVD in IBD. Springer International Publishing 2020-08-12 2020 /pmc/articles/PMC7568702/ /pubmed/32785793 http://dx.doi.org/10.1007/s10238-020-00639-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Czubkowski, Piotr
Osiecki, Marcin
Szymańska, Edyta
Kierkuś, Jarosław
The risk of cardiovascular complications in inflammatory bowel disease
title The risk of cardiovascular complications in inflammatory bowel disease
title_full The risk of cardiovascular complications in inflammatory bowel disease
title_fullStr The risk of cardiovascular complications in inflammatory bowel disease
title_full_unstemmed The risk of cardiovascular complications in inflammatory bowel disease
title_short The risk of cardiovascular complications in inflammatory bowel disease
title_sort risk of cardiovascular complications in inflammatory bowel disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568702/
https://www.ncbi.nlm.nih.gov/pubmed/32785793
http://dx.doi.org/10.1007/s10238-020-00639-y
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