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Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics

Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of all female cancers. The disease shows high intertumoral and intratumoral heterogeneity posing diagnostic and therapeutic challenges with unpredictable clinical outcome and response to existing therapy. Mounting ev...

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Detalles Bibliográficos
Autores principales: Tuasha, Nigatu, Petros, Beyene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568790/
https://www.ncbi.nlm.nih.gov/pubmed/33133722
http://dx.doi.org/10.1155/2020/4736091
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author Tuasha, Nigatu
Petros, Beyene
author_facet Tuasha, Nigatu
Petros, Beyene
author_sort Tuasha, Nigatu
collection PubMed
description Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of all female cancers. The disease shows high intertumoral and intratumoral heterogeneity posing diagnostic and therapeutic challenges with unpredictable clinical outcome and response to existing therapy. Mounting evidence is ascertaining that breast cancer stem cells (CSCs) are responsible for tumor initiation, progression, recurrence, evolution, metastasis, and drug resistance. Therapeutics selectively targeting the CSCs based on distinct surface molecular markers and enhanced intracellular activities of these cells continue to evolve and hold significant promise. Having plethora of heterogeneity accompanied with failure of existing conventional therapeutics and poor prognosis, the present review focuses on elucidating the main signaling pathways in breast CSCs as major therapeutic targets. The role of developments in nanomedicine and miRNA as targeted delivery of therapeutic anticancer agents is also highlighted.
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spelling pubmed-75687902020-10-30 Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics Tuasha, Nigatu Petros, Beyene Scientifica (Cairo) Review Article Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of all female cancers. The disease shows high intertumoral and intratumoral heterogeneity posing diagnostic and therapeutic challenges with unpredictable clinical outcome and response to existing therapy. Mounting evidence is ascertaining that breast cancer stem cells (CSCs) are responsible for tumor initiation, progression, recurrence, evolution, metastasis, and drug resistance. Therapeutics selectively targeting the CSCs based on distinct surface molecular markers and enhanced intracellular activities of these cells continue to evolve and hold significant promise. Having plethora of heterogeneity accompanied with failure of existing conventional therapeutics and poor prognosis, the present review focuses on elucidating the main signaling pathways in breast CSCs as major therapeutic targets. The role of developments in nanomedicine and miRNA as targeted delivery of therapeutic anticancer agents is also highlighted. Hindawi 2020-10-08 /pmc/articles/PMC7568790/ /pubmed/33133722 http://dx.doi.org/10.1155/2020/4736091 Text en Copyright © 2020 Nigatu Tuasha and Beyene Petros. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tuasha, Nigatu
Petros, Beyene
Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
title Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
title_full Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
title_fullStr Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
title_full_unstemmed Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
title_short Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
title_sort heterogeneity of tumors in breast cancer: implications and prospects for prognosis and therapeutics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568790/
https://www.ncbi.nlm.nih.gov/pubmed/33133722
http://dx.doi.org/10.1155/2020/4736091
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