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Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of all female cancers. The disease shows high intertumoral and intratumoral heterogeneity posing diagnostic and therapeutic challenges with unpredictable clinical outcome and response to existing therapy. Mounting ev...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568790/ https://www.ncbi.nlm.nih.gov/pubmed/33133722 http://dx.doi.org/10.1155/2020/4736091 |
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author | Tuasha, Nigatu Petros, Beyene |
author_facet | Tuasha, Nigatu Petros, Beyene |
author_sort | Tuasha, Nigatu |
collection | PubMed |
description | Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of all female cancers. The disease shows high intertumoral and intratumoral heterogeneity posing diagnostic and therapeutic challenges with unpredictable clinical outcome and response to existing therapy. Mounting evidence is ascertaining that breast cancer stem cells (CSCs) are responsible for tumor initiation, progression, recurrence, evolution, metastasis, and drug resistance. Therapeutics selectively targeting the CSCs based on distinct surface molecular markers and enhanced intracellular activities of these cells continue to evolve and hold significant promise. Having plethora of heterogeneity accompanied with failure of existing conventional therapeutics and poor prognosis, the present review focuses on elucidating the main signaling pathways in breast CSCs as major therapeutic targets. The role of developments in nanomedicine and miRNA as targeted delivery of therapeutic anticancer agents is also highlighted. |
format | Online Article Text |
id | pubmed-7568790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75687902020-10-30 Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics Tuasha, Nigatu Petros, Beyene Scientifica (Cairo) Review Article Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of all female cancers. The disease shows high intertumoral and intratumoral heterogeneity posing diagnostic and therapeutic challenges with unpredictable clinical outcome and response to existing therapy. Mounting evidence is ascertaining that breast cancer stem cells (CSCs) are responsible for tumor initiation, progression, recurrence, evolution, metastasis, and drug resistance. Therapeutics selectively targeting the CSCs based on distinct surface molecular markers and enhanced intracellular activities of these cells continue to evolve and hold significant promise. Having plethora of heterogeneity accompanied with failure of existing conventional therapeutics and poor prognosis, the present review focuses on elucidating the main signaling pathways in breast CSCs as major therapeutic targets. The role of developments in nanomedicine and miRNA as targeted delivery of therapeutic anticancer agents is also highlighted. Hindawi 2020-10-08 /pmc/articles/PMC7568790/ /pubmed/33133722 http://dx.doi.org/10.1155/2020/4736091 Text en Copyright © 2020 Nigatu Tuasha and Beyene Petros. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tuasha, Nigatu Petros, Beyene Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics |
title | Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics |
title_full | Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics |
title_fullStr | Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics |
title_full_unstemmed | Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics |
title_short | Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics |
title_sort | heterogeneity of tumors in breast cancer: implications and prospects for prognosis and therapeutics |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568790/ https://www.ncbi.nlm.nih.gov/pubmed/33133722 http://dx.doi.org/10.1155/2020/4736091 |
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