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Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy
BACKGROUND/AIM: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk fac...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568907/ https://www.ncbi.nlm.nih.gov/pubmed/32592358 http://dx.doi.org/10.31557/APJCP.2020.21.6.1637 |
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author | Maniglia, Mauricio Pereira Russo, Anelise Biselli-Chicote, Patrícia Matos de Oliveira-Cucolo, Juliana Garcia Rodrigues-Fleming, Gabriela Helena Maniglia, José Victor Pavarino, Érika Cristina Goloni-Bertollo, Eny Maria |
author_facet | Maniglia, Mauricio Pereira Russo, Anelise Biselli-Chicote, Patrícia Matos de Oliveira-Cucolo, Juliana Garcia Rodrigues-Fleming, Gabriela Helena Maniglia, José Victor Pavarino, Érika Cristina Goloni-Bertollo, Eny Maria |
author_sort | Maniglia, Mauricio Pereira |
collection | PubMed |
description | BACKGROUND/AIM: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. METHODS: The GST gene polymorphisms were evaluated in 197 cases and 514 controls by PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism. RESULTS: The GSTP-313 was associated with a decreased risk for HNSCC (p=0.050). The GSTP1 haplotype analysis revealed a higher frequency of the AC and AT haplotypes in the case group than in the control group (p=0.013 and p=0.019, respectively), and the opposite for G-C haplotype (p = 0.015). Yet, the different combinations between the genotypes were associated with an increased risk of cancer. The study showed no association between the polymorphisms and primary tumor site, clinical-pathological characteristics, treatment (chemotherapy and/or radiotherapy) and survival time of the patients. CONCLUSION: The GST polymorphisms combination showed an increased risk for carcinogenesis, and studies with larger casuistry can contribute to the clarification of the role in individual patient differences for the response to chemotherapy and/or radiotherapy and identify biomarkers of susceptibility. |
format | Online Article Text |
id | pubmed-7568907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-75689072020-10-30 Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy Maniglia, Mauricio Pereira Russo, Anelise Biselli-Chicote, Patrícia Matos de Oliveira-Cucolo, Juliana Garcia Rodrigues-Fleming, Gabriela Helena Maniglia, José Victor Pavarino, Érika Cristina Goloni-Bertollo, Eny Maria Asian Pac J Cancer Prev Research Article BACKGROUND/AIM: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. METHODS: The GST gene polymorphisms were evaluated in 197 cases and 514 controls by PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism. RESULTS: The GSTP-313 was associated with a decreased risk for HNSCC (p=0.050). The GSTP1 haplotype analysis revealed a higher frequency of the AC and AT haplotypes in the case group than in the control group (p=0.013 and p=0.019, respectively), and the opposite for G-C haplotype (p = 0.015). Yet, the different combinations between the genotypes were associated with an increased risk of cancer. The study showed no association between the polymorphisms and primary tumor site, clinical-pathological characteristics, treatment (chemotherapy and/or radiotherapy) and survival time of the patients. CONCLUSION: The GST polymorphisms combination showed an increased risk for carcinogenesis, and studies with larger casuistry can contribute to the clarification of the role in individual patient differences for the response to chemotherapy and/or radiotherapy and identify biomarkers of susceptibility. West Asia Organization for Cancer Prevention 2020-06 /pmc/articles/PMC7568907/ /pubmed/32592358 http://dx.doi.org/10.31557/APJCP.2020.21.6.1637 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Maniglia, Mauricio Pereira Russo, Anelise Biselli-Chicote, Patrícia Matos de Oliveira-Cucolo, Juliana Garcia Rodrigues-Fleming, Gabriela Helena Maniglia, José Victor Pavarino, Érika Cristina Goloni-Bertollo, Eny Maria Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy |
title |
Glutathione
S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy |
title_full |
Glutathione
S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy |
title_fullStr |
Glutathione
S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy |
title_full_unstemmed |
Glutathione
S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy |
title_short |
Glutathione
S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy |
title_sort | glutathione
s-transferase polymorphisms in head and neck squamous cell carcinoma treated with chemotherapy and/or radiotherapy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568907/ https://www.ncbi.nlm.nih.gov/pubmed/32592358 http://dx.doi.org/10.31557/APJCP.2020.21.6.1637 |
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