Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)

The appropriateness of verification of the possible antiviral effect of dinitrosyl iron complexes with thiol-containing ligands as donors of nitrosonium cations (NO(+)) is argued. There is reason to hope that treatment of the human respiratory tract and lungs with sprayed solutions of dinitrosyl iro...

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Autor principal: Vanin, A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2020
Materias:
Discussions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569104/
https://www.ncbi.nlm.nih.gov/pubmed/33100351
http://dx.doi.org/10.1134/S0006350920040260
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author Vanin, A. F.
author_facet Vanin, A. F.
author_sort Vanin, A. F.
collection PubMed
description The appropriateness of verification of the possible antiviral effect of dinitrosyl iron complexes with thiol-containing ligands as donors of nitrosonium cations (NO(+)) is argued. There is reason to hope that treatment of the human respiratory tract and lungs with sprayed solutions of dinitrosyl iron complexes with glutathione or N-acetylcysteine (NAC) ​​as NO(+) donors during COVID-19 infection can initiate S-nitrosylation of cellular proteases and thereby suppress viral infection.
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spelling pubmed-75691042020-10-19 Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis) Vanin, A. F. Biophysics (Oxf) Discussions The appropriateness of verification of the possible antiviral effect of dinitrosyl iron complexes with thiol-containing ligands as donors of nitrosonium cations (NO(+)) is argued. There is reason to hope that treatment of the human respiratory tract and lungs with sprayed solutions of dinitrosyl iron complexes with glutathione or N-acetylcysteine (NAC) ​​as NO(+) donors during COVID-19 infection can initiate S-nitrosylation of cellular proteases and thereby suppress viral infection. Pleiades Publishing 2020-10-19 2020 /pmc/articles/PMC7569104/ /pubmed/33100351 http://dx.doi.org/10.1134/S0006350920040260 Text en © Pleiades Publishing, Inc. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Discussions
Vanin, A. F.
Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)
title Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)
title_full Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)
title_fullStr Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)
title_full_unstemmed Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)
title_short Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis)
title_sort dinitrosyl iron complexes with thiol-containing ligands can suppress viral infections as donors of the nitrosonium cation (hypothesis)
topic Discussions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569104/
https://www.ncbi.nlm.nih.gov/pubmed/33100351
http://dx.doi.org/10.1134/S0006350920040260
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