Cargando…

Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets

BACKGROUND: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. OBJECTIVE: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS), in Orally Disintegrating Tablets (ODTs). METHODS: The OGS...

Descripción completa

Detalles Bibliográficos
Autores principales: Dang, Yen N.T., Tran, Phuong H.L., Tran, Thao T.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569283/
https://www.ncbi.nlm.nih.gov/pubmed/31660821
http://dx.doi.org/10.2174/1872211313666191029144038
_version_ 1783596699875278848
author Dang, Yen N.T.
Tran, Phuong H.L.
Tran, Thao T.D.
author_facet Dang, Yen N.T.
Tran, Phuong H.L.
Tran, Thao T.D.
author_sort Dang, Yen N.T.
collection PubMed
description BACKGROUND: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. OBJECTIVE: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS), in Orally Disintegrating Tablets (ODTs). METHODS: The OGS was investigated with four different modification processes including only milling, swelling, swelling/milling, and swelling/milling/incubation. The ODTs containing the modified OGS as a disintegrant were prepared by the wet granulation method. Furthermore, an evaluation to assess parameters of tablets, such as weight variation, hardness, friability, wetting time, disintegration time, drug content, and dissolution studies, was performed. RESULTS: The modification of OGS using the swelling/ milling process resulted in a completion of OGS modification, leading to an ideal wetting time, disintegrating time, and dissolution rate. The OGS concentrations also affected the wetting and disintegrating time with the optimal range of ODTs from 15% to 20%. On the other hand, the modification with the incubation processes varied by temperature and time increased the wetting time and disintegrating time. CONCLUSIONS: The modified OGS demonstrated that it is a potential material with the advantages of cost-effectiveness, non-toxicity and easy manufacture in the preparation of ODTs.
format Online
Article
Text
id pubmed-7569283
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Bentham Science Publishers
record_format MEDLINE/PubMed
spelling pubmed-75692832020-10-28 Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets Dang, Yen N.T. Tran, Phuong H.L. Tran, Thao T.D. Recent Pat Drug Deliv Formul Article BACKGROUND: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. OBJECTIVE: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS), in Orally Disintegrating Tablets (ODTs). METHODS: The OGS was investigated with four different modification processes including only milling, swelling, swelling/milling, and swelling/milling/incubation. The ODTs containing the modified OGS as a disintegrant were prepared by the wet granulation method. Furthermore, an evaluation to assess parameters of tablets, such as weight variation, hardness, friability, wetting time, disintegration time, drug content, and dissolution studies, was performed. RESULTS: The modification of OGS using the swelling/ milling process resulted in a completion of OGS modification, leading to an ideal wetting time, disintegrating time, and dissolution rate. The OGS concentrations also affected the wetting and disintegrating time with the optimal range of ODTs from 15% to 20%. On the other hand, the modification with the incubation processes varied by temperature and time increased the wetting time and disintegrating time. CONCLUSIONS: The modified OGS demonstrated that it is a potential material with the advantages of cost-effectiveness, non-toxicity and easy manufacture in the preparation of ODTs. Bentham Science Publishers 2020-03 2020-03 /pmc/articles/PMC7569283/ /pubmed/31660821 http://dx.doi.org/10.2174/1872211313666191029144038 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Dang, Yen N.T.
Tran, Phuong H.L.
Tran, Thao T.D.
Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets
title Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets
title_full Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets
title_fullStr Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets
title_full_unstemmed Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets
title_short Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets
title_sort development of the modified ocimum gratissimum seeds for orally disintegrating tablets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569283/
https://www.ncbi.nlm.nih.gov/pubmed/31660821
http://dx.doi.org/10.2174/1872211313666191029144038
work_keys_str_mv AT dangyennt developmentofthemodifiedocimumgratissimumseedsfororallydisintegratingtablets
AT tranphuonghl developmentofthemodifiedocimumgratissimumseedsfororallydisintegratingtablets
AT tranthaotd developmentofthemodifiedocimumgratissimumseedsfororallydisintegratingtablets