X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine

BACKGROUND: Para-nitrophenyl phosphate, the common substrate for alkaline phosphatase (AP), is available as a cyclohexylamine salt. Here, we report that cyclohexylamine is a non-competitive inhibitor of APs. METHODS: Cyclohexylamine inhibited four different APs. Co-crystallization with the cold-acti...

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Detalles Bibliográficos
Autores principales: Ásgeirsson, Bjarni, Markússon, Sigurbjörn, Hlynsdóttir, Sigríður S., Helland, Ronny, Hjörleifsson, Jens G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569297/
https://www.ncbi.nlm.nih.gov/pubmed/33102813
http://dx.doi.org/10.1016/j.bbrep.2020.100830

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