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Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells

Cutaneous T-cell lymphomas and leukemias (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas. These are characterized by an accumulation of malignant CD4(+) T-lymphocytes in the skin, lymph nodes, and peripheral blood. Novel treatment options are needed for patients who prog...

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Detalles Bibliográficos
Autores principales:	Brouwer, Isabella J., Out-Luiting, Jacoba J., Vermeer, Maarten H., Tensen, Cornelis P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569298/ https://www.ncbi.nlm.nih.gov/pubmed/33102814 http://dx.doi.org/10.1016/j.bbrep.2020.100832

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