Role of Grina/Nmdara1 in the Central Nervous System Diseases

Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been re...

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Detalles Bibliográficos
Autores principales: Chen, Kai, Yang, Liu Nan, Lai, Chuan, Liu, Dan, Zhu, Ling-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569322/
https://www.ncbi.nlm.nih.gov/pubmed/32124700
http://dx.doi.org/10.2174/1570159X18666200303104235
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author Chen, Kai
Yang, Liu Nan
Lai, Chuan
Liu, Dan
Zhu, Ling-Qiang
author_facet Chen, Kai
Yang, Liu Nan
Lai, Chuan
Liu, Dan
Zhu, Ling-Qiang
author_sort Chen, Kai
collection PubMed
description Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple diseases in human beings, such as major depressive disorder (MDD) and schizophrenia (SCZ), with which the underlying mechanisms remain elusive. In this review, we provide a general overview of the expression and physiological function of GRINA in the central nervous system (CNS) diseases, including stroke, depression, epilepsy, SCZ, and Alzheimer’s disease (AD).
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spelling pubmed-75693222021-03-01 Role of Grina/Nmdara1 in the Central Nervous System Diseases Chen, Kai Yang, Liu Nan Lai, Chuan Liu, Dan Zhu, Ling-Qiang Curr Neuropharmacol Article Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple diseases in human beings, such as major depressive disorder (MDD) and schizophrenia (SCZ), with which the underlying mechanisms remain elusive. In this review, we provide a general overview of the expression and physiological function of GRINA in the central nervous system (CNS) diseases, including stroke, depression, epilepsy, SCZ, and Alzheimer’s disease (AD). Bentham Science Publishers 2020-09 2020-09 /pmc/articles/PMC7569322/ /pubmed/32124700 http://dx.doi.org/10.2174/1570159X18666200303104235 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Chen, Kai
Yang, Liu Nan
Lai, Chuan
Liu, Dan
Zhu, Ling-Qiang
Role of Grina/Nmdara1 in the Central Nervous System Diseases
title Role of Grina/Nmdara1 in the Central Nervous System Diseases
title_full Role of Grina/Nmdara1 in the Central Nervous System Diseases
title_fullStr Role of Grina/Nmdara1 in the Central Nervous System Diseases
title_full_unstemmed Role of Grina/Nmdara1 in the Central Nervous System Diseases
title_short Role of Grina/Nmdara1 in the Central Nervous System Diseases
title_sort role of grina/nmdara1 in the central nervous system diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569322/
https://www.ncbi.nlm.nih.gov/pubmed/32124700
http://dx.doi.org/10.2174/1570159X18666200303104235
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