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Investigating the potential impact of post translational modification of auto-antigens by tissue transglutaminase on humoral islet autoimmunity in type 1 diabetes

BACKGROUND: Post-translational modification (PTM) of antigens plays a role in the pathogenesis of many autoimmune disorders. In coeliac disease (CD), tissue transglutaminase (tTG) deamidates gliadin peptides to activate the immune response against the gut endomysium. CD is six times more prevalent i...

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Detalles Bibliográficos
Autores principales:	Donnelly, Catherine, Williams, Alistair
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569324/ https://www.ncbi.nlm.nih.gov/pubmed/33103101 http://dx.doi.org/10.1016/j.metop.2020.100062

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