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Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem

Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and...

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Detalles Bibliográficos
Autores principales: Pamies, David, Zurich, Marie-Gabrielle, Hartung, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569333/
https://www.ncbi.nlm.nih.gov/pubmed/33103073
http://dx.doi.org/10.1016/j.isci.2020.101633
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author Pamies, David
Zurich, Marie-Gabrielle
Hartung, Thomas
author_facet Pamies, David
Zurich, Marie-Gabrielle
Hartung, Thomas
author_sort Pamies, David
collection PubMed
description Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and in vitro cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma.
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spelling pubmed-75693332020-10-22 Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem Pamies, David Zurich, Marie-Gabrielle Hartung, Thomas iScience Review Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and in vitro cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma. Elsevier 2020-10-01 /pmc/articles/PMC7569333/ /pubmed/33103073 http://dx.doi.org/10.1016/j.isci.2020.101633 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Pamies, David
Zurich, Marie-Gabrielle
Hartung, Thomas
Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
title Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
title_full Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
title_fullStr Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
title_full_unstemmed Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
title_short Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
title_sort organotypic models to study human glioblastoma: studying the beast in its ecosystem
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569333/
https://www.ncbi.nlm.nih.gov/pubmed/33103073
http://dx.doi.org/10.1016/j.isci.2020.101633
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