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Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569333/ https://www.ncbi.nlm.nih.gov/pubmed/33103073 http://dx.doi.org/10.1016/j.isci.2020.101633 |
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author | Pamies, David Zurich, Marie-Gabrielle Hartung, Thomas |
author_facet | Pamies, David Zurich, Marie-Gabrielle Hartung, Thomas |
author_sort | Pamies, David |
collection | PubMed |
description | Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and in vitro cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma. |
format | Online Article Text |
id | pubmed-7569333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75693332020-10-22 Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem Pamies, David Zurich, Marie-Gabrielle Hartung, Thomas iScience Review Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and in vitro cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma. Elsevier 2020-10-01 /pmc/articles/PMC7569333/ /pubmed/33103073 http://dx.doi.org/10.1016/j.isci.2020.101633 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Pamies, David Zurich, Marie-Gabrielle Hartung, Thomas Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem |
title | Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem |
title_full | Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem |
title_fullStr | Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem |
title_full_unstemmed | Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem |
title_short | Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem |
title_sort | organotypic models to study human glioblastoma: studying the beast in its ecosystem |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569333/ https://www.ncbi.nlm.nih.gov/pubmed/33103073 http://dx.doi.org/10.1016/j.isci.2020.101633 |
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