Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT

Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake...

Descripción completa

Detalles Bibliográficos
Autores principales: Farahi, Neda, Gillett, Daniel, Southwood, Mark, Rassl, Doris, Tregay, Nicola, Hill, Uta, Preston, Stephen Denis, Loutsios, Chrystalla, Lok, Laurence Si Chong, Heard, Sarah, Buscombe, John, Rintoul, Robert Campbell, Peters, A Michael, Summers, Charlotte, Chilvers, Edwin R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Chest Clinic
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569370/
https://www.ncbi.nlm.nih.gov/pubmed/32887739
http://dx.doi.org/10.1136/thoraxjnl-2020-214642
Descripción
Sumario:Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.

Ejemplares similares