Unfolded protein response in the COVID-19 context

The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in...

Descripción completa

Detalles Bibliográficos
Autor principal: Barabutis, Nektarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569417/
https://www.ncbi.nlm.nih.gov/pubmed/33330852
http://dx.doi.org/10.1016/j.ahr.2020.100001
_version_ 1783596726754476032
author Barabutis, Nektarios
author_facet Barabutis, Nektarios
author_sort Barabutis, Nektarios
collection PubMed
description The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in the irreversible outcomes of the SARS-CoV-2 - inflicted acute respiratory distress syndrome (ARDS). Thus, it is highly probable that the targeted activation of those UPR components in charge of repairing the destructed lung endothelium of the COVID-19 patients, may deliver a promising therapeutic possibility for those subjected to the devastating outcomes of the ongoing pandemic.
format Online
Article
Text
id pubmed-7569417
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Authors. Published by Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-75694172020-10-19 Unfolded protein response in the COVID-19 context Barabutis, Nektarios Aging Health Res Article The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in the irreversible outcomes of the SARS-CoV-2 - inflicted acute respiratory distress syndrome (ARDS). Thus, it is highly probable that the targeted activation of those UPR components in charge of repairing the destructed lung endothelium of the COVID-19 patients, may deliver a promising therapeutic possibility for those subjected to the devastating outcomes of the ongoing pandemic. The Authors. Published by Elsevier B.V. 2021-03 2020-10-19 /pmc/articles/PMC7569417/ /pubmed/33330852 http://dx.doi.org/10.1016/j.ahr.2020.100001 Text en © 2020 The Authors. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Barabutis, Nektarios
Unfolded protein response in the COVID-19 context
title Unfolded protein response in the COVID-19 context
title_full Unfolded protein response in the COVID-19 context
title_fullStr Unfolded protein response in the COVID-19 context
title_full_unstemmed Unfolded protein response in the COVID-19 context
title_short Unfolded protein response in the COVID-19 context
title_sort unfolded protein response in the covid-19 context
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569417/
https://www.ncbi.nlm.nih.gov/pubmed/33330852
http://dx.doi.org/10.1016/j.ahr.2020.100001
work_keys_str_mv AT barabutisnektarios unfoldedproteinresponseinthecovid19context

Ejemplares similares