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Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications
Intrinsic cancer cells and the tumor-infiltrating immune cells (TIICs) recruited to the immune microenvironment define the malignant phenotype of lung squamous cell carcinoma (LUSC). Understanding more about the immune microenvironment of LUSC enables the selection of high-risk patients who would de...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569448/ https://www.ncbi.nlm.nih.gov/pubmed/33102584 http://dx.doi.org/10.1155/2020/5981870 |
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author | Zhao, Jungang Bao, Wenming Cai, Weiyang |
author_facet | Zhao, Jungang Bao, Wenming Cai, Weiyang |
author_sort | Zhao, Jungang |
collection | PubMed |
description | Intrinsic cancer cells and the tumor-infiltrating immune cells (TIICs) recruited to the immune microenvironment define the malignant phenotype of lung squamous cell carcinoma (LUSC). Understanding more about the immune microenvironment of LUSC enables the selection of high-risk patients who would derive benefit from immunotherapy. Based on large public LUSC cohorts obtained from TCGA and GEO datasets, 22 types of infiltrating immune cell subgroups were evaluated by CIBERSORT. Meta-analysis, principal component analysis (PCA), single-sample gene set enrichment analysis (ssGSEA), and hierarchical clustering analysis were used to evaluate specific immune responses of LUSC. The distribution of TIICs of LUSC was entirely different from normal. TIIC subpopulations were also found to be closely associated with clinical features and molecular subtypes. Unsupervised clustering analysis revealed that three distinct TIIC subgroups existed with different survival patterns. TIICs are extensively implicated in the pathogenesis and development of LUSC. Characterizing the composition of TIICs influences the metabolism, pathological stage, and survival of tumor patients. It is hoped that this immune landscape could provide a more accurate understanding of the development and immunotherapy of LUSC. |
format | Online Article Text |
id | pubmed-7569448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75694482020-10-22 Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications Zhao, Jungang Bao, Wenming Cai, Weiyang Biomed Res Int Research Article Intrinsic cancer cells and the tumor-infiltrating immune cells (TIICs) recruited to the immune microenvironment define the malignant phenotype of lung squamous cell carcinoma (LUSC). Understanding more about the immune microenvironment of LUSC enables the selection of high-risk patients who would derive benefit from immunotherapy. Based on large public LUSC cohorts obtained from TCGA and GEO datasets, 22 types of infiltrating immune cell subgroups were evaluated by CIBERSORT. Meta-analysis, principal component analysis (PCA), single-sample gene set enrichment analysis (ssGSEA), and hierarchical clustering analysis were used to evaluate specific immune responses of LUSC. The distribution of TIICs of LUSC was entirely different from normal. TIIC subpopulations were also found to be closely associated with clinical features and molecular subtypes. Unsupervised clustering analysis revealed that three distinct TIIC subgroups existed with different survival patterns. TIICs are extensively implicated in the pathogenesis and development of LUSC. Characterizing the composition of TIICs influences the metabolism, pathological stage, and survival of tumor patients. It is hoped that this immune landscape could provide a more accurate understanding of the development and immunotherapy of LUSC. Hindawi 2020-10-10 /pmc/articles/PMC7569448/ /pubmed/33102584 http://dx.doi.org/10.1155/2020/5981870 Text en Copyright © 2020 Jungang Zhao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhao, Jungang Bao, Wenming Cai, Weiyang Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications |
title | Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications |
title_full | Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications |
title_fullStr | Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications |
title_full_unstemmed | Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications |
title_short | Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications |
title_sort | immune infiltration landscape in lung squamous cell carcinoma implications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569448/ https://www.ncbi.nlm.nih.gov/pubmed/33102584 http://dx.doi.org/10.1155/2020/5981870 |
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