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Serum Amyloid A in lung transplantation
BACKGROUND: Serum Amyloid A (SAA) is an acute phase protein and we analyzed its concentrations in lung transplantated patients (LTX). METHODS: 26 LTX patients (58.6 ± 11 years) and 11 healthy controls (55 ± 11.3 years). Three groups of LTX patients: acute rejection (AR, 7) bronchiolitis obliterans s...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Mattioli 1885
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569538/ https://www.ncbi.nlm.nih.gov/pubmed/33093763 http://dx.doi.org/10.36141/svdld.v37i1.8775 |
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| author | Vietri, Lucia Bargagli, Elena Bennett, David Fossi, Antonella Cameli, Paolo Bergantini, Laura d’Alessandro, Miriana Paladini, Piero Luzzi, Luca Gentili, Francesco Mazzei, Maria Antonietta Spina, Donatella Sestini, Piersante Rottoli, Paola |
| author_facet | Vietri, Lucia Bargagli, Elena Bennett, David Fossi, Antonella Cameli, Paolo Bergantini, Laura d’Alessandro, Miriana Paladini, Piero Luzzi, Luca Gentili, Francesco Mazzei, Maria Antonietta Spina, Donatella Sestini, Piersante Rottoli, Paola |
| author_sort | Vietri, Lucia |
| collection | PubMed |
| description | BACKGROUND: Serum Amyloid A (SAA) is an acute phase protein and we analyzed its concentrations in lung transplantated patients (LTX). METHODS: 26 LTX patients (58.6 ± 11 years) and 11 healthy controls (55 ± 11.3 years). Three groups of LTX patients: acute rejection (AR, 7) bronchiolitis obliterans syndrome (BOS, 3), acute infection (INF, 9) and stable patients (NEG, 7). RESULTS: In LTX patients SAA concentrations were significantly increased, particularly in AR and INF. In LTX-AR patients were observed a correlation between SAA levels and peripheral CD4+ lymphocyte percentage (r=0.9, p<0.01) and a reverse correlation with FVC percentages (r -0.94, p=0.01). CONCLUSIONS: SAA may represent a potential biomarker of LTX acute complications, with a prognostic value in AR. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (1): 2-7) |
| format | Online Article Text |
| id | pubmed-7569538 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Mattioli 1885 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75695382020-10-21 Serum Amyloid A in lung transplantation Vietri, Lucia Bargagli, Elena Bennett, David Fossi, Antonella Cameli, Paolo Bergantini, Laura d’Alessandro, Miriana Paladini, Piero Luzzi, Luca Gentili, Francesco Mazzei, Maria Antonietta Spina, Donatella Sestini, Piersante Rottoli, Paola Sarcoidosis Vasc Diffuse Lung Dis Original Article: Clinical Research BACKGROUND: Serum Amyloid A (SAA) is an acute phase protein and we analyzed its concentrations in lung transplantated patients (LTX). METHODS: 26 LTX patients (58.6 ± 11 years) and 11 healthy controls (55 ± 11.3 years). Three groups of LTX patients: acute rejection (AR, 7) bronchiolitis obliterans syndrome (BOS, 3), acute infection (INF, 9) and stable patients (NEG, 7). RESULTS: In LTX patients SAA concentrations were significantly increased, particularly in AR and INF. In LTX-AR patients were observed a correlation between SAA levels and peripheral CD4+ lymphocyte percentage (r=0.9, p<0.01) and a reverse correlation with FVC percentages (r -0.94, p=0.01). CONCLUSIONS: SAA may represent a potential biomarker of LTX acute complications, with a prognostic value in AR. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (1): 2-7) Mattioli 1885 2020 2020-03-15 /pmc/articles/PMC7569538/ /pubmed/33093763 http://dx.doi.org/10.36141/svdld.v37i1.8775 Text en Copyright: © 2020 SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License |
| spellingShingle | Original Article: Clinical Research Vietri, Lucia Bargagli, Elena Bennett, David Fossi, Antonella Cameli, Paolo Bergantini, Laura d’Alessandro, Miriana Paladini, Piero Luzzi, Luca Gentili, Francesco Mazzei, Maria Antonietta Spina, Donatella Sestini, Piersante Rottoli, Paola Serum Amyloid A in lung transplantation |
| title | Serum Amyloid A in lung transplantation |
| title_full | Serum Amyloid A in lung transplantation |
| title_fullStr | Serum Amyloid A in lung transplantation |
| title_full_unstemmed | Serum Amyloid A in lung transplantation |
| title_short | Serum Amyloid A in lung transplantation |
| title_sort | serum amyloid a in lung transplantation |
| topic | Original Article: Clinical Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569538/ https://www.ncbi.nlm.nih.gov/pubmed/33093763 http://dx.doi.org/10.36141/svdld.v37i1.8775 |
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