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Predictors of cough-specific and generic quality of life in sarcoidosis patients

BACKGROUND: Cough is frequent symptom in sarcoidosis and its impact on patient’s quality of life (QoL) has not been adequately addressed so far. OBJECTIVES: The goal of this study was to determine the significant predictors of cough-specific and generic QoL in sarcoidosis patients. METHODS: In the p...

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Autores principales: Gvozdenovic, Branislav S., Mihailovic-Vucinic, Violeta V., Vukovic, Mira H., Stjepanovic, Mihailo I., Buha, Ivana, Mihailovic, Strahinja V., Maric, Nikola B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569550/
https://www.ncbi.nlm.nih.gov/pubmed/33093779
http://dx.doi.org/10.36141/svdld.v37i2.9234
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author Gvozdenovic, Branislav S.
Mihailovic-Vucinic, Violeta V.
Vukovic, Mira H.
Stjepanovic, Mihailo I.
Buha, Ivana
Mihailovic, Strahinja V.
Maric, Nikola B.
author_facet Gvozdenovic, Branislav S.
Mihailovic-Vucinic, Violeta V.
Vukovic, Mira H.
Stjepanovic, Mihailo I.
Buha, Ivana
Mihailovic, Strahinja V.
Maric, Nikola B.
author_sort Gvozdenovic, Branislav S.
collection PubMed
description BACKGROUND: Cough is frequent symptom in sarcoidosis and its impact on patient’s quality of life (QoL) has not been adequately addressed so far. OBJECTIVES: The goal of this study was to determine the significant predictors of cough-specific and generic QoL in sarcoidosis patients. METHODS: In the prospective study 275 sarcoidosis patients administered Patient Reported Outcomes instruments for measurement of dyspnea (Borg and MRC scales) and fatigue (Fatigue Assessment Scale (FAS) and Daily Activity List (DAL)), as well as patients’ QoL (cough-specific Leicester Cough Questionnaire (LCQ) and generic tool – 15D). The LCQ contains 3 domains covering physical, psychological and social aspects of chronic cough. Pulmonary function tests (spirometry and diffusing capacity for carbon monoxide) and serum angiotensin converting enzyme (sACE) were also measured. RESULTS: Dyspnea measured by Borg scale and impairment of daily activities determined by DAL instrument as well as sACE were the strongest predictors of all cough-specific QoL domains. Mental aspect of patients’ fatigue was significantly correlated with all domains except with psychological LCQ domain. Regarding the generic QoL, the following significant predictors were: dyspnea measured by MRC scale, overall fatigue determined by FAS and physical domain of the LCQ. CONCLUSION: It is important to measure both cough-specific and generic QoL in sarcoidosis patients since they measure different health aspects and their predictors can be different. We demonstrated that physical domain of cough-specific QoL is significant predictor of generic QoL. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (2): 158-168)
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spelling pubmed-75695502020-10-21 Predictors of cough-specific and generic quality of life in sarcoidosis patients Gvozdenovic, Branislav S. Mihailovic-Vucinic, Violeta V. Vukovic, Mira H. Stjepanovic, Mihailo I. Buha, Ivana Mihailovic, Strahinja V. Maric, Nikola B. Sarcoidosis Vasc Diffuse Lung Dis Original Article: Clinical Research BACKGROUND: Cough is frequent symptom in sarcoidosis and its impact on patient’s quality of life (QoL) has not been adequately addressed so far. OBJECTIVES: The goal of this study was to determine the significant predictors of cough-specific and generic QoL in sarcoidosis patients. METHODS: In the prospective study 275 sarcoidosis patients administered Patient Reported Outcomes instruments for measurement of dyspnea (Borg and MRC scales) and fatigue (Fatigue Assessment Scale (FAS) and Daily Activity List (DAL)), as well as patients’ QoL (cough-specific Leicester Cough Questionnaire (LCQ) and generic tool – 15D). The LCQ contains 3 domains covering physical, psychological and social aspects of chronic cough. Pulmonary function tests (spirometry and diffusing capacity for carbon monoxide) and serum angiotensin converting enzyme (sACE) were also measured. RESULTS: Dyspnea measured by Borg scale and impairment of daily activities determined by DAL instrument as well as sACE were the strongest predictors of all cough-specific QoL domains. Mental aspect of patients’ fatigue was significantly correlated with all domains except with psychological LCQ domain. Regarding the generic QoL, the following significant predictors were: dyspnea measured by MRC scale, overall fatigue determined by FAS and physical domain of the LCQ. CONCLUSION: It is important to measure both cough-specific and generic QoL in sarcoidosis patients since they measure different health aspects and their predictors can be different. We demonstrated that physical domain of cough-specific QoL is significant predictor of generic QoL. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (2): 158-168) Mattioli 1885 2020 2020-06-30 /pmc/articles/PMC7569550/ /pubmed/33093779 http://dx.doi.org/10.36141/svdld.v37i2.9234 Text en Copyright: © 2020 SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Original Article: Clinical Research
Gvozdenovic, Branislav S.
Mihailovic-Vucinic, Violeta V.
Vukovic, Mira H.
Stjepanovic, Mihailo I.
Buha, Ivana
Mihailovic, Strahinja V.
Maric, Nikola B.
Predictors of cough-specific and generic quality of life in sarcoidosis patients
title Predictors of cough-specific and generic quality of life in sarcoidosis patients
title_full Predictors of cough-specific and generic quality of life in sarcoidosis patients
title_fullStr Predictors of cough-specific and generic quality of life in sarcoidosis patients
title_full_unstemmed Predictors of cough-specific and generic quality of life in sarcoidosis patients
title_short Predictors of cough-specific and generic quality of life in sarcoidosis patients
title_sort predictors of cough-specific and generic quality of life in sarcoidosis patients
topic Original Article: Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569550/
https://www.ncbi.nlm.nih.gov/pubmed/33093779
http://dx.doi.org/10.36141/svdld.v37i2.9234
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