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Amino acids and fatty acids in patients with beta thalassemia major

BACKGROUND: Oxidative damage and increasing of lipid peroxidation are caused by chronic iron overload in patients with beta thalassemia major. Fatty acids are important structural elements for palmitoylation of membrane proteins which constitute a great part of natural membranes. Oxidative damages c...

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Autores principales: Koca, Tuğba, Canatan, Duran, Örmeci, Ahmet Rifat, Koca, Yavuz Savaş, Duman, Handan, Baykal, Aslı, Akçam, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569589/
https://www.ncbi.nlm.nih.gov/pubmed/32191658
http://dx.doi.org/10.23750/abm.v91i1.7266
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author Koca, Tuğba
Canatan, Duran
Örmeci, Ahmet Rifat
Koca, Yavuz Savaş
Duman, Handan
Baykal, Aslı
Akçam, Mustafa
author_facet Koca, Tuğba
Canatan, Duran
Örmeci, Ahmet Rifat
Koca, Yavuz Savaş
Duman, Handan
Baykal, Aslı
Akçam, Mustafa
author_sort Koca, Tuğba
collection PubMed
description BACKGROUND: Oxidative damage and increasing of lipid peroxidation are caused by chronic iron overload in patients with beta thalassemia major. Fatty acids are important structural elements for palmitoylation of membrane proteins which constitute a great part of natural membranes. Oxidative damages caused by reactive oxygen derives in thalassemic erythrocytes can be determined with lipid peroxidation, protein oxidation, and antioxidant system elements. The aim of study was to evaluate the relationship between amino acid and fatty acid levels with iron overload and antioxidant enzymes in beta thalassemia major. METHODS: A total 40 patients with beta thalassemia major with regular blood transfusion and chelating agents were included in the study. The levels of serum amino acid, fatty acid, ferritin, antioxidant enzymes and malondialdehyde were measured. RESULTS: Only C16-palmitoyl level was found significantly low in patients, other fatty acids and amino acids were in normal range. There were lower malondialdehyde and ferritin levels in patients with low C-16 palmitoyl level (p<0.05). CONCLUSIONS: The high levels of ferritin and malondialdehyde in the patients with low C16-palmitoyl levels might be caused by this fatty acid’s preventative effect on oxidative stress. (www.actabiomedica.it)
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spelling pubmed-75695892020-10-21 Amino acids and fatty acids in patients with beta thalassemia major Koca, Tuğba Canatan, Duran Örmeci, Ahmet Rifat Koca, Yavuz Savaş Duman, Handan Baykal, Aslı Akçam, Mustafa Acta Biomed Original Article BACKGROUND: Oxidative damage and increasing of lipid peroxidation are caused by chronic iron overload in patients with beta thalassemia major. Fatty acids are important structural elements for palmitoylation of membrane proteins which constitute a great part of natural membranes. Oxidative damages caused by reactive oxygen derives in thalassemic erythrocytes can be determined with lipid peroxidation, protein oxidation, and antioxidant system elements. The aim of study was to evaluate the relationship between amino acid and fatty acid levels with iron overload and antioxidant enzymes in beta thalassemia major. METHODS: A total 40 patients with beta thalassemia major with regular blood transfusion and chelating agents were included in the study. The levels of serum amino acid, fatty acid, ferritin, antioxidant enzymes and malondialdehyde were measured. RESULTS: Only C16-palmitoyl level was found significantly low in patients, other fatty acids and amino acids were in normal range. There were lower malondialdehyde and ferritin levels in patients with low C-16 palmitoyl level (p<0.05). CONCLUSIONS: The high levels of ferritin and malondialdehyde in the patients with low C16-palmitoyl levels might be caused by this fatty acid’s preventative effect on oxidative stress. (www.actabiomedica.it) Mattioli 1885 2020 2020-03-19 /pmc/articles/PMC7569589/ /pubmed/32191658 http://dx.doi.org/10.23750/abm.v91i1.7266 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Original Article
Koca, Tuğba
Canatan, Duran
Örmeci, Ahmet Rifat
Koca, Yavuz Savaş
Duman, Handan
Baykal, Aslı
Akçam, Mustafa
Amino acids and fatty acids in patients with beta thalassemia major
title Amino acids and fatty acids in patients with beta thalassemia major
title_full Amino acids and fatty acids in patients with beta thalassemia major
title_fullStr Amino acids and fatty acids in patients with beta thalassemia major
title_full_unstemmed Amino acids and fatty acids in patients with beta thalassemia major
title_short Amino acids and fatty acids in patients with beta thalassemia major
title_sort amino acids and fatty acids in patients with beta thalassemia major
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569589/
https://www.ncbi.nlm.nih.gov/pubmed/32191658
http://dx.doi.org/10.23750/abm.v91i1.7266
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