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Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations

Chitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostati...

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Autores principales: Lovskaya, Daria, Menshutina, Natalia, Mochalova, Maria, Nosov, Artem, Grebenyuk, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570265/
https://www.ncbi.nlm.nih.gov/pubmed/32927608
http://dx.doi.org/10.3390/polym12092055
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author Lovskaya, Daria
Menshutina, Natalia
Mochalova, Maria
Nosov, Artem
Grebenyuk, Alexander
author_facet Lovskaya, Daria
Menshutina, Natalia
Mochalova, Maria
Nosov, Artem
Grebenyuk, Alexander
author_sort Lovskaya, Daria
collection PubMed
description Chitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostatic efficacy of chitosan-based aerogel particles was studied in vivo on a model of damage of a large vessel in the deep wound. Pigs were used as test animals. It was shown that primary hemostasis was achieved, there were no signs of rebleeding and aerogel particles were tightly fixed to the walls of the wound canal. A dense clot was formed inside the wound (at the femoral artery), which indicates stable hemostasis. This study demonstrated that chitosan-based aerogel particles have a high sorption capacity and are highly effective as local hemostatic agents which can be used to stop massive bleeding.
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spelling pubmed-75702652020-10-28 Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations Lovskaya, Daria Menshutina, Natalia Mochalova, Maria Nosov, Artem Grebenyuk, Alexander Polymers (Basel) Article Chitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostatic efficacy of chitosan-based aerogel particles was studied in vivo on a model of damage of a large vessel in the deep wound. Pigs were used as test animals. It was shown that primary hemostasis was achieved, there were no signs of rebleeding and aerogel particles were tightly fixed to the walls of the wound canal. A dense clot was formed inside the wound (at the femoral artery), which indicates stable hemostasis. This study demonstrated that chitosan-based aerogel particles have a high sorption capacity and are highly effective as local hemostatic agents which can be used to stop massive bleeding. MDPI 2020-09-10 /pmc/articles/PMC7570265/ /pubmed/32927608 http://dx.doi.org/10.3390/polym12092055 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lovskaya, Daria
Menshutina, Natalia
Mochalova, Maria
Nosov, Artem
Grebenyuk, Alexander
Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations
title Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations
title_full Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations
title_fullStr Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations
title_full_unstemmed Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations
title_short Chitosan-Based Aerogel Particles as Highly Effective Local Hemostatic Agents. Production Process and In Vivo Evaluations
title_sort chitosan-based aerogel particles as highly effective local hemostatic agents. production process and in vivo evaluations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570265/
https://www.ncbi.nlm.nih.gov/pubmed/32927608
http://dx.doi.org/10.3390/polym12092055
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