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Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity
The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe(3)O(4) nanoparticles were incorporated into the PLLA bone scaffold prepared by selec...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570298/ https://www.ncbi.nlm.nih.gov/pubmed/32911730 http://dx.doi.org/10.3390/polym12092045 |
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author | Bin, Shizhen Wang, Ailun Guo, Wang Yu, Li Feng, Pei |
author_facet | Bin, Shizhen Wang, Ailun Guo, Wang Yu, Li Feng, Pei |
author_sort | Bin, Shizhen |
collection | PubMed |
description | The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe(3)O(4) nanoparticles were incorporated into the PLLA bone scaffold prepared by selective laser sintering (SLS) for continuously and steadily enhancing cellular activity. In the scaffold, each Fe(3)O(4) nanoparticle was a single magnetic domain without a domain wall, providing a micro-magnetic source to generate a tiny magnetic field, thereby continuously and steadily generating magnetic stimulation to cells. The results showed that the magnetic scaffold exhibited superparamagnetism and its saturation magnetization reached a maximum value of 6.1 emu/g. It promoted the attachment, diffusion, and interaction of MG63 cells, and increased the activity of alkaline phosphatase, thus promoting the cell proliferation and differentiation. Meanwhile, the scaffold with 7% Fe(3)O(4) presented increased compressive strength, modulus, and Vickers hardness by 63.4%, 78.9%, and 19.1% compared with the PLLA scaffold, respectively, due to the addition of Fe(3)O(4) nanoparticles, which act as a nanoscale reinforcement in the polymer matrix. All these positive results suggested that the PLLA/Fe(3)O(4) scaffold with good magnetic properties is of great potential for bone tissue engineering applications. |
format | Online Article Text |
id | pubmed-7570298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75702982020-10-28 Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity Bin, Shizhen Wang, Ailun Guo, Wang Yu, Li Feng, Pei Polymers (Basel) Article The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe(3)O(4) nanoparticles were incorporated into the PLLA bone scaffold prepared by selective laser sintering (SLS) for continuously and steadily enhancing cellular activity. In the scaffold, each Fe(3)O(4) nanoparticle was a single magnetic domain without a domain wall, providing a micro-magnetic source to generate a tiny magnetic field, thereby continuously and steadily generating magnetic stimulation to cells. The results showed that the magnetic scaffold exhibited superparamagnetism and its saturation magnetization reached a maximum value of 6.1 emu/g. It promoted the attachment, diffusion, and interaction of MG63 cells, and increased the activity of alkaline phosphatase, thus promoting the cell proliferation and differentiation. Meanwhile, the scaffold with 7% Fe(3)O(4) presented increased compressive strength, modulus, and Vickers hardness by 63.4%, 78.9%, and 19.1% compared with the PLLA scaffold, respectively, due to the addition of Fe(3)O(4) nanoparticles, which act as a nanoscale reinforcement in the polymer matrix. All these positive results suggested that the PLLA/Fe(3)O(4) scaffold with good magnetic properties is of great potential for bone tissue engineering applications. MDPI 2020-09-08 /pmc/articles/PMC7570298/ /pubmed/32911730 http://dx.doi.org/10.3390/polym12092045 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bin, Shizhen Wang, Ailun Guo, Wang Yu, Li Feng, Pei Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity |
title | Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity |
title_full | Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity |
title_fullStr | Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity |
title_full_unstemmed | Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity |
title_short | Micro Magnetic Field Produced by Fe(3)O(4) Nanoparticles in Bone Scaffold for Enhancing Cellular Activity |
title_sort | micro magnetic field produced by fe(3)o(4) nanoparticles in bone scaffold for enhancing cellular activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570298/ https://www.ncbi.nlm.nih.gov/pubmed/32911730 http://dx.doi.org/10.3390/polym12092045 |
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