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Caenorhabditis elegans as a Useful Model for Studying Aging Mutations

The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human disease genes. Based on its physiological aging characteristics and superiority, the use of C. elegans as a model system for studies on aging, age-related diseases, mechanisms of longevity, and drug screening has b...

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Autores principales: Zhang, Siwen, Li, Fei, Zhou, Tong, Wang, Guixia, Li, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570440/
https://www.ncbi.nlm.nih.gov/pubmed/33123086
http://dx.doi.org/10.3389/fendo.2020.554994
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author Zhang, Siwen
Li, Fei
Zhou, Tong
Wang, Guixia
Li, Zhuo
author_facet Zhang, Siwen
Li, Fei
Zhou, Tong
Wang, Guixia
Li, Zhuo
author_sort Zhang, Siwen
collection PubMed
description The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human disease genes. Based on its physiological aging characteristics and superiority, the use of C. elegans as a model system for studies on aging, age-related diseases, mechanisms of longevity, and drug screening has been widely acknowledged in recent decades. Lifespan increasing mutations in C. elegans were found to delay aging by impinging several signaling pathways and related epigenetic modifications, including the insulin/IGF-1 signaling (IIS), AMP-activated protein kinase (AMPK), and mechanistic target of rapamycin (mTOR) pathways. Interestingly, dietary restriction (DR) has been shown to increase the lifespan of numerous metazoans and protect them from multiple age-related pathologies. However, the underlying molecular mechanisms are unclear. In recent decades, C. elegans has been used as a unique model system for high-throughput drug screening. Here, we review C. elegans mutants exhibiting increased in lifespan and age-dependent changes under DR, as well as the utility of C. elegans for drug screening. Thus, we provide evidence for the use of this model organism in research on the prevention of aging.
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spelling pubmed-75704402020-10-28 Caenorhabditis elegans as a Useful Model for Studying Aging Mutations Zhang, Siwen Li, Fei Zhou, Tong Wang, Guixia Li, Zhuo Front Endocrinol (Lausanne) Endocrinology The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human disease genes. Based on its physiological aging characteristics and superiority, the use of C. elegans as a model system for studies on aging, age-related diseases, mechanisms of longevity, and drug screening has been widely acknowledged in recent decades. Lifespan increasing mutations in C. elegans were found to delay aging by impinging several signaling pathways and related epigenetic modifications, including the insulin/IGF-1 signaling (IIS), AMP-activated protein kinase (AMPK), and mechanistic target of rapamycin (mTOR) pathways. Interestingly, dietary restriction (DR) has been shown to increase the lifespan of numerous metazoans and protect them from multiple age-related pathologies. However, the underlying molecular mechanisms are unclear. In recent decades, C. elegans has been used as a unique model system for high-throughput drug screening. Here, we review C. elegans mutants exhibiting increased in lifespan and age-dependent changes under DR, as well as the utility of C. elegans for drug screening. Thus, we provide evidence for the use of this model organism in research on the prevention of aging. Frontiers Media S.A. 2020-10-05 /pmc/articles/PMC7570440/ /pubmed/33123086 http://dx.doi.org/10.3389/fendo.2020.554994 Text en Copyright © 2020 Zhang, Li, Zhou, Wang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhang, Siwen
Li, Fei
Zhou, Tong
Wang, Guixia
Li, Zhuo
Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
title Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
title_full Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
title_fullStr Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
title_full_unstemmed Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
title_short Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
title_sort caenorhabditis elegans as a useful model for studying aging mutations
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570440/
https://www.ncbi.nlm.nih.gov/pubmed/33123086
http://dx.doi.org/10.3389/fendo.2020.554994
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