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Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human disease genes. Based on its physiological aging characteristics and superiority, the use of C. elegans as a model system for studies on aging, age-related diseases, mechanisms of longevity, and drug screening has b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570440/ https://www.ncbi.nlm.nih.gov/pubmed/33123086 http://dx.doi.org/10.3389/fendo.2020.554994 |
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author | Zhang, Siwen Li, Fei Zhou, Tong Wang, Guixia Li, Zhuo |
author_facet | Zhang, Siwen Li, Fei Zhou, Tong Wang, Guixia Li, Zhuo |
author_sort | Zhang, Siwen |
collection | PubMed |
description | The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human disease genes. Based on its physiological aging characteristics and superiority, the use of C. elegans as a model system for studies on aging, age-related diseases, mechanisms of longevity, and drug screening has been widely acknowledged in recent decades. Lifespan increasing mutations in C. elegans were found to delay aging by impinging several signaling pathways and related epigenetic modifications, including the insulin/IGF-1 signaling (IIS), AMP-activated protein kinase (AMPK), and mechanistic target of rapamycin (mTOR) pathways. Interestingly, dietary restriction (DR) has been shown to increase the lifespan of numerous metazoans and protect them from multiple age-related pathologies. However, the underlying molecular mechanisms are unclear. In recent decades, C. elegans has been used as a unique model system for high-throughput drug screening. Here, we review C. elegans mutants exhibiting increased in lifespan and age-dependent changes under DR, as well as the utility of C. elegans for drug screening. Thus, we provide evidence for the use of this model organism in research on the prevention of aging. |
format | Online Article Text |
id | pubmed-7570440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75704402020-10-28 Caenorhabditis elegans as a Useful Model for Studying Aging Mutations Zhang, Siwen Li, Fei Zhou, Tong Wang, Guixia Li, Zhuo Front Endocrinol (Lausanne) Endocrinology The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human disease genes. Based on its physiological aging characteristics and superiority, the use of C. elegans as a model system for studies on aging, age-related diseases, mechanisms of longevity, and drug screening has been widely acknowledged in recent decades. Lifespan increasing mutations in C. elegans were found to delay aging by impinging several signaling pathways and related epigenetic modifications, including the insulin/IGF-1 signaling (IIS), AMP-activated protein kinase (AMPK), and mechanistic target of rapamycin (mTOR) pathways. Interestingly, dietary restriction (DR) has been shown to increase the lifespan of numerous metazoans and protect them from multiple age-related pathologies. However, the underlying molecular mechanisms are unclear. In recent decades, C. elegans has been used as a unique model system for high-throughput drug screening. Here, we review C. elegans mutants exhibiting increased in lifespan and age-dependent changes under DR, as well as the utility of C. elegans for drug screening. Thus, we provide evidence for the use of this model organism in research on the prevention of aging. Frontiers Media S.A. 2020-10-05 /pmc/articles/PMC7570440/ /pubmed/33123086 http://dx.doi.org/10.3389/fendo.2020.554994 Text en Copyright © 2020 Zhang, Li, Zhou, Wang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Zhang, Siwen Li, Fei Zhou, Tong Wang, Guixia Li, Zhuo Caenorhabditis elegans as a Useful Model for Studying Aging Mutations |
title | Caenorhabditis elegans as a Useful Model for Studying Aging Mutations |
title_full | Caenorhabditis elegans as a Useful Model for Studying Aging Mutations |
title_fullStr | Caenorhabditis elegans as a Useful Model for Studying Aging Mutations |
title_full_unstemmed | Caenorhabditis elegans as a Useful Model for Studying Aging Mutations |
title_short | Caenorhabditis elegans as a Useful Model for Studying Aging Mutations |
title_sort | caenorhabditis elegans as a useful model for studying aging mutations |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570440/ https://www.ncbi.nlm.nih.gov/pubmed/33123086 http://dx.doi.org/10.3389/fendo.2020.554994 |
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