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The Lipidome Fingerprint of Longevity
Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570520/ https://www.ncbi.nlm.nih.gov/pubmed/32971886 http://dx.doi.org/10.3390/molecules25184343 |
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author | Jové, Mariona Mota-Martorell, Natàlia Pradas, Irene Galo-Licona, José Daniel Martín-Gari, Meritxell Obis, Èlia Sol, Joaquim Pamplona, Reinald |
author_facet | Jové, Mariona Mota-Martorell, Natàlia Pradas, Irene Galo-Licona, José Daniel Martín-Gari, Meritxell Obis, Èlia Sol, Joaquim Pamplona, Reinald |
author_sort | Jové, Mariona |
collection | PubMed |
description | Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life. |
format | Online Article Text |
id | pubmed-7570520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75705202020-10-28 The Lipidome Fingerprint of Longevity Jové, Mariona Mota-Martorell, Natàlia Pradas, Irene Galo-Licona, José Daniel Martín-Gari, Meritxell Obis, Èlia Sol, Joaquim Pamplona, Reinald Molecules Review Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life. MDPI 2020-09-22 /pmc/articles/PMC7570520/ /pubmed/32971886 http://dx.doi.org/10.3390/molecules25184343 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jové, Mariona Mota-Martorell, Natàlia Pradas, Irene Galo-Licona, José Daniel Martín-Gari, Meritxell Obis, Èlia Sol, Joaquim Pamplona, Reinald The Lipidome Fingerprint of Longevity |
title | The Lipidome Fingerprint of Longevity |
title_full | The Lipidome Fingerprint of Longevity |
title_fullStr | The Lipidome Fingerprint of Longevity |
title_full_unstemmed | The Lipidome Fingerprint of Longevity |
title_short | The Lipidome Fingerprint of Longevity |
title_sort | lipidome fingerprint of longevity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570520/ https://www.ncbi.nlm.nih.gov/pubmed/32971886 http://dx.doi.org/10.3390/molecules25184343 |
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