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The Lipidome Fingerprint of Longevity

Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal...

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Autores principales: Jové, Mariona, Mota-Martorell, Natàlia, Pradas, Irene, Galo-Licona, José Daniel, Martín-Gari, Meritxell, Obis, Èlia, Sol, Joaquim, Pamplona, Reinald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570520/
https://www.ncbi.nlm.nih.gov/pubmed/32971886
http://dx.doi.org/10.3390/molecules25184343
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author Jové, Mariona
Mota-Martorell, Natàlia
Pradas, Irene
Galo-Licona, José Daniel
Martín-Gari, Meritxell
Obis, Èlia
Sol, Joaquim
Pamplona, Reinald
author_facet Jové, Mariona
Mota-Martorell, Natàlia
Pradas, Irene
Galo-Licona, José Daniel
Martín-Gari, Meritxell
Obis, Èlia
Sol, Joaquim
Pamplona, Reinald
author_sort Jové, Mariona
collection PubMed
description Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.
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spelling pubmed-75705202020-10-28 The Lipidome Fingerprint of Longevity Jové, Mariona Mota-Martorell, Natàlia Pradas, Irene Galo-Licona, José Daniel Martín-Gari, Meritxell Obis, Èlia Sol, Joaquim Pamplona, Reinald Molecules Review Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life. MDPI 2020-09-22 /pmc/articles/PMC7570520/ /pubmed/32971886 http://dx.doi.org/10.3390/molecules25184343 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jové, Mariona
Mota-Martorell, Natàlia
Pradas, Irene
Galo-Licona, José Daniel
Martín-Gari, Meritxell
Obis, Èlia
Sol, Joaquim
Pamplona, Reinald
The Lipidome Fingerprint of Longevity
title The Lipidome Fingerprint of Longevity
title_full The Lipidome Fingerprint of Longevity
title_fullStr The Lipidome Fingerprint of Longevity
title_full_unstemmed The Lipidome Fingerprint of Longevity
title_short The Lipidome Fingerprint of Longevity
title_sort lipidome fingerprint of longevity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570520/
https://www.ncbi.nlm.nih.gov/pubmed/32971886
http://dx.doi.org/10.3390/molecules25184343
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