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What are we missing? Three cases of severe COVID-19 pneumonia with negative testing
The COVID-19 pandemic has drastically affected health care systems globally. Reverse transcriptase-polymerase chain reaction is currently the preferred method of detecting COVID-19; however, sensitivity of this test remains questionable. Incidental transmission and potential harm to infected individ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570767/ https://www.ncbi.nlm.nih.gov/pubmed/33117540 http://dx.doi.org/10.1177/2050313X20965410 |
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author | Siddiqui, Aisha Singh, Sukhdev Khan, Zohaib Foster, Allison Atere, Muhammed Nfonoyim, Jay M |
author_facet | Siddiqui, Aisha Singh, Sukhdev Khan, Zohaib Foster, Allison Atere, Muhammed Nfonoyim, Jay M |
author_sort | Siddiqui, Aisha |
collection | PubMed |
description | The COVID-19 pandemic has drastically affected health care systems globally. Reverse transcriptase-polymerase chain reaction is currently the preferred method of detecting COVID-19; however, sensitivity of this test remains questionable. Incidental transmission and potential harm to infected individuals are some consequences of the failure to identify high-risk patients. We report three cases of symptomatic patients that required intensive care management with labs and imaging consistent with COVID-19 with initial false-negative reverse transcriptase-polymerase chain reaction testing. Improper sampling, viral load, and manufacturer variances of tests all contribute to reduced sensitivity. A clinical diagnosis should supplant such cases. |
format | Online Article Text |
id | pubmed-7570767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75707672020-10-27 What are we missing? Three cases of severe COVID-19 pneumonia with negative testing Siddiqui, Aisha Singh, Sukhdev Khan, Zohaib Foster, Allison Atere, Muhammed Nfonoyim, Jay M SAGE Open Med Case Rep Case Report The COVID-19 pandemic has drastically affected health care systems globally. Reverse transcriptase-polymerase chain reaction is currently the preferred method of detecting COVID-19; however, sensitivity of this test remains questionable. Incidental transmission and potential harm to infected individuals are some consequences of the failure to identify high-risk patients. We report three cases of symptomatic patients that required intensive care management with labs and imaging consistent with COVID-19 with initial false-negative reverse transcriptase-polymerase chain reaction testing. Improper sampling, viral load, and manufacturer variances of tests all contribute to reduced sensitivity. A clinical diagnosis should supplant such cases. SAGE Publications 2020-10-15 /pmc/articles/PMC7570767/ /pubmed/33117540 http://dx.doi.org/10.1177/2050313X20965410 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Siddiqui, Aisha Singh, Sukhdev Khan, Zohaib Foster, Allison Atere, Muhammed Nfonoyim, Jay M What are we missing? Three cases of severe COVID-19 pneumonia with negative testing |
title | What are we missing? Three cases of severe COVID-19 pneumonia with negative testing |
title_full | What are we missing? Three cases of severe COVID-19 pneumonia with negative testing |
title_fullStr | What are we missing? Three cases of severe COVID-19 pneumonia with negative testing |
title_full_unstemmed | What are we missing? Three cases of severe COVID-19 pneumonia with negative testing |
title_short | What are we missing? Three cases of severe COVID-19 pneumonia with negative testing |
title_sort | what are we missing? three cases of severe covid-19 pneumonia with negative testing |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570767/ https://www.ncbi.nlm.nih.gov/pubmed/33117540 http://dx.doi.org/10.1177/2050313X20965410 |
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