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What are we missing? Three cases of severe COVID-19 pneumonia with negative testing

The COVID-19 pandemic has drastically affected health care systems globally. Reverse transcriptase-polymerase chain reaction is currently the preferred method of detecting COVID-19; however, sensitivity of this test remains questionable. Incidental transmission and potential harm to infected individ...

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Autores principales: Siddiqui, Aisha, Singh, Sukhdev, Khan, Zohaib, Foster, Allison, Atere, Muhammed, Nfonoyim, Jay M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570767/
https://www.ncbi.nlm.nih.gov/pubmed/33117540
http://dx.doi.org/10.1177/2050313X20965410
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author Siddiqui, Aisha
Singh, Sukhdev
Khan, Zohaib
Foster, Allison
Atere, Muhammed
Nfonoyim, Jay M
author_facet Siddiqui, Aisha
Singh, Sukhdev
Khan, Zohaib
Foster, Allison
Atere, Muhammed
Nfonoyim, Jay M
author_sort Siddiqui, Aisha
collection PubMed
description The COVID-19 pandemic has drastically affected health care systems globally. Reverse transcriptase-polymerase chain reaction is currently the preferred method of detecting COVID-19; however, sensitivity of this test remains questionable. Incidental transmission and potential harm to infected individuals are some consequences of the failure to identify high-risk patients. We report three cases of symptomatic patients that required intensive care management with labs and imaging consistent with COVID-19 with initial false-negative reverse transcriptase-polymerase chain reaction testing. Improper sampling, viral load, and manufacturer variances of tests all contribute to reduced sensitivity. A clinical diagnosis should supplant such cases.
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spelling pubmed-75707672020-10-27 What are we missing? Three cases of severe COVID-19 pneumonia with negative testing Siddiqui, Aisha Singh, Sukhdev Khan, Zohaib Foster, Allison Atere, Muhammed Nfonoyim, Jay M SAGE Open Med Case Rep Case Report The COVID-19 pandemic has drastically affected health care systems globally. Reverse transcriptase-polymerase chain reaction is currently the preferred method of detecting COVID-19; however, sensitivity of this test remains questionable. Incidental transmission and potential harm to infected individuals are some consequences of the failure to identify high-risk patients. We report three cases of symptomatic patients that required intensive care management with labs and imaging consistent with COVID-19 with initial false-negative reverse transcriptase-polymerase chain reaction testing. Improper sampling, viral load, and manufacturer variances of tests all contribute to reduced sensitivity. A clinical diagnosis should supplant such cases. SAGE Publications 2020-10-15 /pmc/articles/PMC7570767/ /pubmed/33117540 http://dx.doi.org/10.1177/2050313X20965410 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Siddiqui, Aisha
Singh, Sukhdev
Khan, Zohaib
Foster, Allison
Atere, Muhammed
Nfonoyim, Jay M
What are we missing? Three cases of severe COVID-19 pneumonia with negative testing
title What are we missing? Three cases of severe COVID-19 pneumonia with negative testing
title_full What are we missing? Three cases of severe COVID-19 pneumonia with negative testing
title_fullStr What are we missing? Three cases of severe COVID-19 pneumonia with negative testing
title_full_unstemmed What are we missing? Three cases of severe COVID-19 pneumonia with negative testing
title_short What are we missing? Three cases of severe COVID-19 pneumonia with negative testing
title_sort what are we missing? three cases of severe covid-19 pneumonia with negative testing
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570767/
https://www.ncbi.nlm.nih.gov/pubmed/33117540
http://dx.doi.org/10.1177/2050313X20965410
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