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Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence

While cannabis has been consumed for thousands of years, the medical-legal landscape surrounding its use has dramatically evolved over the past decades. Patients are turning to cannabis as a therapeutic option for several medical conditions. Given the surge in interest over the past decades there ex...

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Detalles Bibliográficos
Autores principales: Ladha, Karim S., Ajrawat, Prabjit, Yang, Yi, Clarke, Hance
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570835/
https://www.ncbi.nlm.nih.gov/pubmed/32899678
http://dx.doi.org/10.3390/molecules25184042
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author Ladha, Karim S.
Ajrawat, Prabjit
Yang, Yi
Clarke, Hance
author_facet Ladha, Karim S.
Ajrawat, Prabjit
Yang, Yi
Clarke, Hance
author_sort Ladha, Karim S.
collection PubMed
description While cannabis has been consumed for thousands of years, the medical-legal landscape surrounding its use has dramatically evolved over the past decades. Patients are turning to cannabis as a therapeutic option for several medical conditions. Given the surge in interest over the past decades there exists a major gap in the literature with respect to understanding the products that are currently being consumed by patients. The current perspective highlights the lack of relevance within the current literature towards understanding the medical chemistry of the products being consumed. The cannabis industry must rigorously invest into understanding what people are consuming from a chemical composition standpoint. This will inform what compounds in addition to Δ(9)-tetrahydrocannabinol and cannabidiol may be producing physiologic/therapeutic effects from plant based extracts. Only through real-world evidence and a formalized, granular data collection process within which we know the chemical inputs for patients already using or beginning to use medical cannabis, we can come closer to the ability to provide targeted clinical decision making and design future appropriate randomized controlled trials.
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spelling pubmed-75708352020-10-28 Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence Ladha, Karim S. Ajrawat, Prabjit Yang, Yi Clarke, Hance Molecules Communication While cannabis has been consumed for thousands of years, the medical-legal landscape surrounding its use has dramatically evolved over the past decades. Patients are turning to cannabis as a therapeutic option for several medical conditions. Given the surge in interest over the past decades there exists a major gap in the literature with respect to understanding the products that are currently being consumed by patients. The current perspective highlights the lack of relevance within the current literature towards understanding the medical chemistry of the products being consumed. The cannabis industry must rigorously invest into understanding what people are consuming from a chemical composition standpoint. This will inform what compounds in addition to Δ(9)-tetrahydrocannabinol and cannabidiol may be producing physiologic/therapeutic effects from plant based extracts. Only through real-world evidence and a formalized, granular data collection process within which we know the chemical inputs for patients already using or beginning to use medical cannabis, we can come closer to the ability to provide targeted clinical decision making and design future appropriate randomized controlled trials. MDPI 2020-09-04 /pmc/articles/PMC7570835/ /pubmed/32899678 http://dx.doi.org/10.3390/molecules25184042 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ladha, Karim S.
Ajrawat, Prabjit
Yang, Yi
Clarke, Hance
Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence
title Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence
title_full Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence
title_fullStr Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence
title_full_unstemmed Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence
title_short Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence
title_sort understanding the medical chemistry of the cannabis plant is critical to guiding real world clinical evidence
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570835/
https://www.ncbi.nlm.nih.gov/pubmed/32899678
http://dx.doi.org/10.3390/molecules25184042
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