Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to

The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukemia and acute lymphoblastic leukemia. The auto-inhibition regulatory module observed in the progenitor kinase c-Abl is lost in the aberrant Bcr-Abl, because of the lack of the N-myristoylated cap able...

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Detalles Bibliográficos
Autores principales: Carofiglio, Francesca, Trisciuzzi, Daniela, Gambacorta, Nicola, Leonetti, Francesco, Stefanachi, Angela, Nicolotti, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570842/
https://www.ncbi.nlm.nih.gov/pubmed/32937901
http://dx.doi.org/10.3390/molecules25184210

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