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Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompa...

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Detalles Bibliográficos
Autores principales: Chimisso, Vittoria, Aleman Garcia, Miguel Angel, Yorulmaz Avsar, Saziye, Dinu, Ionel Adrian, Palivan, Cornelia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571016/
https://www.ncbi.nlm.nih.gov/pubmed/32906772
http://dx.doi.org/10.3390/molecules25184090
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author Chimisso, Vittoria
Aleman Garcia, Miguel Angel
Yorulmaz Avsar, Saziye
Dinu, Ionel Adrian
Palivan, Cornelia G.
author_facet Chimisso, Vittoria
Aleman Garcia, Miguel Angel
Yorulmaz Avsar, Saziye
Dinu, Ionel Adrian
Palivan, Cornelia G.
author_sort Chimisso, Vittoria
collection PubMed
description Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.
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spelling pubmed-75710162020-10-28 Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice Chimisso, Vittoria Aleman Garcia, Miguel Angel Yorulmaz Avsar, Saziye Dinu, Ionel Adrian Palivan, Cornelia G. Molecules Review Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications. MDPI 2020-09-07 /pmc/articles/PMC7571016/ /pubmed/32906772 http://dx.doi.org/10.3390/molecules25184090 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chimisso, Vittoria
Aleman Garcia, Miguel Angel
Yorulmaz Avsar, Saziye
Dinu, Ionel Adrian
Palivan, Cornelia G.
Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice
title Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice
title_full Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice
title_fullStr Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice
title_full_unstemmed Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice
title_short Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice
title_sort design of bio-conjugated hydrogels for regenerative medicine applications: from polymer scaffold to biomolecule choice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571016/
https://www.ncbi.nlm.nih.gov/pubmed/32906772
http://dx.doi.org/10.3390/molecules25184090
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