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Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice
Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571016/ https://www.ncbi.nlm.nih.gov/pubmed/32906772 http://dx.doi.org/10.3390/molecules25184090 |
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author | Chimisso, Vittoria Aleman Garcia, Miguel Angel Yorulmaz Avsar, Saziye Dinu, Ionel Adrian Palivan, Cornelia G. |
author_facet | Chimisso, Vittoria Aleman Garcia, Miguel Angel Yorulmaz Avsar, Saziye Dinu, Ionel Adrian Palivan, Cornelia G. |
author_sort | Chimisso, Vittoria |
collection | PubMed |
description | Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications. |
format | Online Article Text |
id | pubmed-7571016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75710162020-10-28 Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice Chimisso, Vittoria Aleman Garcia, Miguel Angel Yorulmaz Avsar, Saziye Dinu, Ionel Adrian Palivan, Cornelia G. Molecules Review Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications. MDPI 2020-09-07 /pmc/articles/PMC7571016/ /pubmed/32906772 http://dx.doi.org/10.3390/molecules25184090 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chimisso, Vittoria Aleman Garcia, Miguel Angel Yorulmaz Avsar, Saziye Dinu, Ionel Adrian Palivan, Cornelia G. Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice |
title | Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice |
title_full | Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice |
title_fullStr | Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice |
title_full_unstemmed | Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice |
title_short | Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice |
title_sort | design of bio-conjugated hydrogels for regenerative medicine applications: from polymer scaffold to biomolecule choice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571016/ https://www.ncbi.nlm.nih.gov/pubmed/32906772 http://dx.doi.org/10.3390/molecules25184090 |
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