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Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment

Acrylamide (AA) is a neo-formed toxic compound that develops in foods during cooking at temperatures above 120 °C. AA shows in vivo neurotoxic and carcinogenic effects, and it is potentially carcinogenic for humans. Its occurrence is common in baked food, such as bread and similar products. This stu...

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Autores principales: Esposito, Francesco, Velotto, Salvatore, Rea, Teresa, Stasi, Tommaso, Cirillo, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571032/
https://www.ncbi.nlm.nih.gov/pubmed/32932804
http://dx.doi.org/10.3390/molecules25184156
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author Esposito, Francesco
Velotto, Salvatore
Rea, Teresa
Stasi, Tommaso
Cirillo, Teresa
author_facet Esposito, Francesco
Velotto, Salvatore
Rea, Teresa
Stasi, Tommaso
Cirillo, Teresa
author_sort Esposito, Francesco
collection PubMed
description Acrylamide (AA) is a neo-formed toxic compound that develops in foods during cooking at temperatures above 120 °C. AA shows in vivo neurotoxic and carcinogenic effects, and it is potentially carcinogenic for humans. Its occurrence is common in baked food, such as bread and similar products. This study set out to analyze bread and sweets from the Italian market to evaluate the effects of the benchmark thresholds set by EU Regulation 2017/2158 and to ascertain the exposure of the Italian population to AA, across three age groups, through the consumption of baked products, according to the margin of exposure (MOE) approach. Two hundred samples were tested, and the content of AA ranged from 31 to 454 µg/kg for bread and products thereof and from 204 to 400 µg/kg for the sweets category. The exposure data did not show any neurotoxic health concern, whereas the MOE related to the carcinogenic endpoint is well below the minimum safety value of 10,000.
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spelling pubmed-75710322020-10-28 Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment Esposito, Francesco Velotto, Salvatore Rea, Teresa Stasi, Tommaso Cirillo, Teresa Molecules Article Acrylamide (AA) is a neo-formed toxic compound that develops in foods during cooking at temperatures above 120 °C. AA shows in vivo neurotoxic and carcinogenic effects, and it is potentially carcinogenic for humans. Its occurrence is common in baked food, such as bread and similar products. This study set out to analyze bread and sweets from the Italian market to evaluate the effects of the benchmark thresholds set by EU Regulation 2017/2158 and to ascertain the exposure of the Italian population to AA, across three age groups, through the consumption of baked products, according to the margin of exposure (MOE) approach. Two hundred samples were tested, and the content of AA ranged from 31 to 454 µg/kg for bread and products thereof and from 204 to 400 µg/kg for the sweets category. The exposure data did not show any neurotoxic health concern, whereas the MOE related to the carcinogenic endpoint is well below the minimum safety value of 10,000. MDPI 2020-09-11 /pmc/articles/PMC7571032/ /pubmed/32932804 http://dx.doi.org/10.3390/molecules25184156 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Esposito, Francesco
Velotto, Salvatore
Rea, Teresa
Stasi, Tommaso
Cirillo, Teresa
Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment
title Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment
title_full Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment
title_fullStr Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment
title_full_unstemmed Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment
title_short Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment
title_sort occurrence of acrylamide in italian baked products and dietary exposure assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571032/
https://www.ncbi.nlm.nih.gov/pubmed/32932804
http://dx.doi.org/10.3390/molecules25184156
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