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A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate
A carbon nanofibers modified screen-printed carbon sensor (SPCE/CNFs) was applied for the determination of a novel promising anticancer agent candidate (ethyl 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3-carboxylate, EIMTC) using square-wave voltammetry (SWV). It is th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571158/ https://www.ncbi.nlm.nih.gov/pubmed/32933116 http://dx.doi.org/10.3390/s20185217 |
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author | Tyszczuk-Rotko, Katarzyna Kozak, Jędrzej Sztanke, Małgorzata Sztanke, Krzysztof Sadok, Ilona |
author_facet | Tyszczuk-Rotko, Katarzyna Kozak, Jędrzej Sztanke, Małgorzata Sztanke, Krzysztof Sadok, Ilona |
author_sort | Tyszczuk-Rotko, Katarzyna |
collection | PubMed |
description | A carbon nanofibers modified screen-printed carbon sensor (SPCE/CNFs) was applied for the determination of a novel promising anticancer agent candidate (ethyl 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3-carboxylate, EIMTC) using square-wave voltammetry (SWV). It is the first method for the quantitative determination of EIMTC. The modified screen-printed sensor exhibited excellent electrochemical activity in reducing EIMTC. The peak current of EIMTC was found to be linear in two concentration ranges of 2.0 × 10(−9) – 2.0 × 10(−8) mol L(−1) and 2.0 × 10(−8) – 2.0 × 10(−7) mol L(−1), with a detection limit of 5.0 × 10(−10) mol L(−1). The connection of flow-cell for the SPCE/CNFs with SWV detection allowed for the successful determination of EIMTC in human serum samples. Ultra-high-performance liquid chromatography coupled to electrospray ionization triple quadrupole mass spectrometry (UHPLC-ESI-MS/MS) acted as a comparative method in the serum samples analysis. |
format | Online Article Text |
id | pubmed-7571158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75711582020-10-28 A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate Tyszczuk-Rotko, Katarzyna Kozak, Jędrzej Sztanke, Małgorzata Sztanke, Krzysztof Sadok, Ilona Sensors (Basel) Article A carbon nanofibers modified screen-printed carbon sensor (SPCE/CNFs) was applied for the determination of a novel promising anticancer agent candidate (ethyl 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3-carboxylate, EIMTC) using square-wave voltammetry (SWV). It is the first method for the quantitative determination of EIMTC. The modified screen-printed sensor exhibited excellent electrochemical activity in reducing EIMTC. The peak current of EIMTC was found to be linear in two concentration ranges of 2.0 × 10(−9) – 2.0 × 10(−8) mol L(−1) and 2.0 × 10(−8) – 2.0 × 10(−7) mol L(−1), with a detection limit of 5.0 × 10(−10) mol L(−1). The connection of flow-cell for the SPCE/CNFs with SWV detection allowed for the successful determination of EIMTC in human serum samples. Ultra-high-performance liquid chromatography coupled to electrospray ionization triple quadrupole mass spectrometry (UHPLC-ESI-MS/MS) acted as a comparative method in the serum samples analysis. MDPI 2020-09-13 /pmc/articles/PMC7571158/ /pubmed/32933116 http://dx.doi.org/10.3390/s20185217 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tyszczuk-Rotko, Katarzyna Kozak, Jędrzej Sztanke, Małgorzata Sztanke, Krzysztof Sadok, Ilona A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate |
title | A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate |
title_full | A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate |
title_fullStr | A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate |
title_full_unstemmed | A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate |
title_short | A Screen-Printed Sensor Coupled with Flow System for Quantitative Determination of a Novel Promising Anticancer Agent Candidate |
title_sort | screen-printed sensor coupled with flow system for quantitative determination of a novel promising anticancer agent candidate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571158/ https://www.ncbi.nlm.nih.gov/pubmed/32933116 http://dx.doi.org/10.3390/s20185217 |
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