The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents

On March 11, 2020, the World Health Organization (WHO) officially declared the outbreak caused by the new coronavirus (SARS-CoV-2) a pandemic. The rapid spread of the disease surprised the scientific and medical community. Based on the latest reports, news, and scientific articles published, there i...

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Autores principales: Villas-Boas, Gustavo R., Rescia, Vanessa C., Paes, Marina M., Lavorato, Stefânia N., de Magalhães-Filho, Manoel F., Cunha, Mila S., Simões, Rafael da C., de Lacerda, Roseli B., de Freitas-Júnior, Renilson S., Ramos, Bruno H. da S., Mapeli, Ana M., Henriques, Matheus da S. T., de Freitas, William R., Lopes, Luiz A. F., Oliveira, Luiz G. R., da Silva, Jonatas G., Silva-Filho, Saulo E., da Silveira, Ana P. S., Leão, Katyuscya V., Matos, Maria M. de S., Fernandes, Jamille S., Cuman, Roberto K. N., Silva-Comar, Francielli M. de S., Comar, Jurandir F., Brasileiro, Luana do A., dos Santos, Jussileide N., Oesterreich, Silvia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571161/
https://www.ncbi.nlm.nih.gov/pubmed/32906733
http://dx.doi.org/10.3390/molecules25184086
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author Villas-Boas, Gustavo R.
Rescia, Vanessa C.
Paes, Marina M.
Lavorato, Stefânia N.
de Magalhães-Filho, Manoel F.
Cunha, Mila S.
Simões, Rafael da C.
de Lacerda, Roseli B.
de Freitas-Júnior, Renilson S.
Ramos, Bruno H. da S.
Mapeli, Ana M.
Henriques, Matheus da S. T.
de Freitas, William R.
Lopes, Luiz A. F.
Oliveira, Luiz G. R.
da Silva, Jonatas G.
Silva-Filho, Saulo E.
da Silveira, Ana P. S.
Leão, Katyuscya V.
Matos, Maria M. de S.
Fernandes, Jamille S.
Cuman, Roberto K. N.
Silva-Comar, Francielli M. de S.
Comar, Jurandir F.
Brasileiro, Luana do A.
dos Santos, Jussileide N.
Oesterreich, Silvia A.
author_facet Villas-Boas, Gustavo R.
Rescia, Vanessa C.
Paes, Marina M.
Lavorato, Stefânia N.
de Magalhães-Filho, Manoel F.
Cunha, Mila S.
Simões, Rafael da C.
de Lacerda, Roseli B.
de Freitas-Júnior, Renilson S.
Ramos, Bruno H. da S.
Mapeli, Ana M.
Henriques, Matheus da S. T.
de Freitas, William R.
Lopes, Luiz A. F.
Oliveira, Luiz G. R.
da Silva, Jonatas G.
Silva-Filho, Saulo E.
da Silveira, Ana P. S.
Leão, Katyuscya V.
Matos, Maria M. de S.
Fernandes, Jamille S.
Cuman, Roberto K. N.
Silva-Comar, Francielli M. de S.
Comar, Jurandir F.
Brasileiro, Luana do A.
dos Santos, Jussileide N.
Oesterreich, Silvia A.
author_sort Villas-Boas, Gustavo R.
collection PubMed
description On March 11, 2020, the World Health Organization (WHO) officially declared the outbreak caused by the new coronavirus (SARS-CoV-2) a pandemic. The rapid spread of the disease surprised the scientific and medical community. Based on the latest reports, news, and scientific articles published, there is no doubt that the coronavirus has overloaded health systems globally. Practical actions against the recent emergence and rapid expansion of the SARS-CoV-2 require the development and use of tools for discovering new molecular anti-SARS-CoV-2 targets. Thus, this review presents bioinformatics and molecular modeling strategies that aim to assist in the discovery of potential anti-SARS-CoV-2 agents. Besides, we reviewed the relationship between SARS-CoV-2 and innate immunity, since understanding the structures involved in this infection can contribute to the development of new therapeutic targets. Bioinformatics is a technology that assists researchers in coping with diseases by investigating genetic sequencing and seeking structural models of potential molecular targets present in SARS-CoV2. The details provided in this review provide future points of consideration in the field of virology and medical sciences that will contribute to clarifying potential therapeutic targets for anti-SARS-CoV-2 and for understanding the molecular mechanisms responsible for the pathogenesis and virulence of SARS-CoV-2.
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spelling pubmed-75711612020-10-28 The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents Villas-Boas, Gustavo R. Rescia, Vanessa C. Paes, Marina M. Lavorato, Stefânia N. de Magalhães-Filho, Manoel F. Cunha, Mila S. Simões, Rafael da C. de Lacerda, Roseli B. de Freitas-Júnior, Renilson S. Ramos, Bruno H. da S. Mapeli, Ana M. Henriques, Matheus da S. T. de Freitas, William R. Lopes, Luiz A. F. Oliveira, Luiz G. R. da Silva, Jonatas G. Silva-Filho, Saulo E. da Silveira, Ana P. S. Leão, Katyuscya V. Matos, Maria M. de S. Fernandes, Jamille S. Cuman, Roberto K. N. Silva-Comar, Francielli M. de S. Comar, Jurandir F. Brasileiro, Luana do A. dos Santos, Jussileide N. Oesterreich, Silvia A. Molecules Review On March 11, 2020, the World Health Organization (WHO) officially declared the outbreak caused by the new coronavirus (SARS-CoV-2) a pandemic. The rapid spread of the disease surprised the scientific and medical community. Based on the latest reports, news, and scientific articles published, there is no doubt that the coronavirus has overloaded health systems globally. Practical actions against the recent emergence and rapid expansion of the SARS-CoV-2 require the development and use of tools for discovering new molecular anti-SARS-CoV-2 targets. Thus, this review presents bioinformatics and molecular modeling strategies that aim to assist in the discovery of potential anti-SARS-CoV-2 agents. Besides, we reviewed the relationship between SARS-CoV-2 and innate immunity, since understanding the structures involved in this infection can contribute to the development of new therapeutic targets. Bioinformatics is a technology that assists researchers in coping with diseases by investigating genetic sequencing and seeking structural models of potential molecular targets present in SARS-CoV2. The details provided in this review provide future points of consideration in the field of virology and medical sciences that will contribute to clarifying potential therapeutic targets for anti-SARS-CoV-2 and for understanding the molecular mechanisms responsible for the pathogenesis and virulence of SARS-CoV-2. MDPI 2020-09-07 /pmc/articles/PMC7571161/ /pubmed/32906733 http://dx.doi.org/10.3390/molecules25184086 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Villas-Boas, Gustavo R.
Rescia, Vanessa C.
Paes, Marina M.
Lavorato, Stefânia N.
de Magalhães-Filho, Manoel F.
Cunha, Mila S.
Simões, Rafael da C.
de Lacerda, Roseli B.
de Freitas-Júnior, Renilson S.
Ramos, Bruno H. da S.
Mapeli, Ana M.
Henriques, Matheus da S. T.
de Freitas, William R.
Lopes, Luiz A. F.
Oliveira, Luiz G. R.
da Silva, Jonatas G.
Silva-Filho, Saulo E.
da Silveira, Ana P. S.
Leão, Katyuscya V.
Matos, Maria M. de S.
Fernandes, Jamille S.
Cuman, Roberto K. N.
Silva-Comar, Francielli M. de S.
Comar, Jurandir F.
Brasileiro, Luana do A.
dos Santos, Jussileide N.
Oesterreich, Silvia A.
The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents
title The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents
title_full The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents
title_fullStr The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents
title_full_unstemmed The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents
title_short The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents
title_sort new coronavirus (sars-cov-2): a comprehensive review on immunity and the application of bioinformatics and molecular modeling to the discovery of potential anti-sars-cov-2 agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571161/
https://www.ncbi.nlm.nih.gov/pubmed/32906733
http://dx.doi.org/10.3390/molecules25184086
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