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A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy

In the development of dermal drug formulations and cosmetics, understanding the penetration properties of the active ingredients is crucial. Given that widespread methods, including tape stripping, lack in spatial resolution, while being time- and labour-intensive, Confocal Raman Microscopy is a pro...

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Detalles Bibliográficos
Autores principales: Krombholz, Richard, Lunter, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571176/
https://www.ncbi.nlm.nih.gov/pubmed/32942565
http://dx.doi.org/10.3390/molecules25184222
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author Krombholz, Richard
Lunter, Dominique
author_facet Krombholz, Richard
Lunter, Dominique
author_sort Krombholz, Richard
collection PubMed
description In the development of dermal drug formulations and cosmetics, understanding the penetration properties of the active ingredients is crucial. Given that widespread methods, including tape stripping, lack in spatial resolution, while being time- and labour-intensive, Confocal Raman Microscopy is a promising alternative. In optimizing topically applied formulations, or the development of generic formulations, comparative in-situ measurements have a huge potential of saving time and resources. In this work, we show our approach to in-situ skin penetration analysis by confocal Raman Microscopy. To analyse feasibility of the approach, we used caffeine solutions as model vehicles and tested the effectiveness of 1,2-pentanediol as a penetration enhancer for delivery to the skin.
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spelling pubmed-75711762020-10-28 A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy Krombholz, Richard Lunter, Dominique Molecules Article In the development of dermal drug formulations and cosmetics, understanding the penetration properties of the active ingredients is crucial. Given that widespread methods, including tape stripping, lack in spatial resolution, while being time- and labour-intensive, Confocal Raman Microscopy is a promising alternative. In optimizing topically applied formulations, or the development of generic formulations, comparative in-situ measurements have a huge potential of saving time and resources. In this work, we show our approach to in-situ skin penetration analysis by confocal Raman Microscopy. To analyse feasibility of the approach, we used caffeine solutions as model vehicles and tested the effectiveness of 1,2-pentanediol as a penetration enhancer for delivery to the skin. MDPI 2020-09-15 /pmc/articles/PMC7571176/ /pubmed/32942565 http://dx.doi.org/10.3390/molecules25184222 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krombholz, Richard
Lunter, Dominique
A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy
title A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy
title_full A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy
title_fullStr A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy
title_full_unstemmed A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy
title_short A New Method for In-Situ Skin Penetration Analysis by Confocal Raman Microscopy
title_sort new method for in-situ skin penetration analysis by confocal raman microscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571176/
https://www.ncbi.nlm.nih.gov/pubmed/32942565
http://dx.doi.org/10.3390/molecules25184222
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