UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF(4): Yb,Tm upconversion nanopa...

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Detalles Bibliográficos
Autores principales: Guryev, Evgenii L., Smyshlyaeva, Anita S., Shilyagina, Natalia Y., Sokolova, Evgeniya A., Shanwar, Samah, Kostyuk, Alexey B., Lyubeshkin, Alexander V., Schulga, Alexey A., Konovalova, Elena V., Lin, Quan, Roy, Indrajit, Balalaeva, Irina V., Deyev, Sergey M., Zvyagin, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571190/
https://www.ncbi.nlm.nih.gov/pubmed/32961731
http://dx.doi.org/10.3390/molecules25184302
Descripción
Sumario:Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF(4): Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

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