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Does Teriparatide Improve Fracture Union?: A Systematic Review

We conducted an updated review of the evidence of teriparatide (TPTD) for fracture healing for the following questions. (1) Does it decrease fracture healing time?; (2) Can it be an alternative treatment for nonunion?; (3) Does it aid the union of atypical femoral fracture (AFF)? We searched PubMed,...

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Detalles Bibliográficos
Autores principales: Yoon, Byung-Ho, Kim, Ki-Choul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Bone and Mineral Research 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571240/
https://www.ncbi.nlm.nih.gov/pubmed/32911581
http://dx.doi.org/10.11005/jbm.2020.27.3.167
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author Yoon, Byung-Ho
Kim, Ki-Choul
author_facet Yoon, Byung-Ho
Kim, Ki-Choul
author_sort Yoon, Byung-Ho
collection PubMed
description We conducted an updated review of the evidence of teriparatide (TPTD) for fracture healing for the following questions. (1) Does it decrease fracture healing time?; (2) Can it be an alternative treatment for nonunion?; (3) Does it aid the union of atypical femoral fracture (AFF)? We searched PubMed, EMBASE, and Cochrane Library including “Fracture” AND “nonunion” AND “Teriparatide”. In total, 57 publications met our inclusion criteria were summarized. This systemic review of the available literature revealed that TPTD works positively with regard to enhancing fracture healing time and union of AFF. There are also many case studies on the use of TPTD could be a potential new safe treatment for nonunion with no side effects. However, level 1 studies on the evidence of TPTD are still lacking so far. Over the last decade, a growing body of evidence has accumulated suggesting that TPTD can be an adjunct to enhance fracture healing or a therapeutic option to treat nonunion, but greater evidences from large volume prospective trials are needed.
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spelling pubmed-75712402020-10-23 Does Teriparatide Improve Fracture Union?: A Systematic Review Yoon, Byung-Ho Kim, Ki-Choul J Bone Metab Review Article We conducted an updated review of the evidence of teriparatide (TPTD) for fracture healing for the following questions. (1) Does it decrease fracture healing time?; (2) Can it be an alternative treatment for nonunion?; (3) Does it aid the union of atypical femoral fracture (AFF)? We searched PubMed, EMBASE, and Cochrane Library including “Fracture” AND “nonunion” AND “Teriparatide”. In total, 57 publications met our inclusion criteria were summarized. This systemic review of the available literature revealed that TPTD works positively with regard to enhancing fracture healing time and union of AFF. There are also many case studies on the use of TPTD could be a potential new safe treatment for nonunion with no side effects. However, level 1 studies on the evidence of TPTD are still lacking so far. Over the last decade, a growing body of evidence has accumulated suggesting that TPTD can be an adjunct to enhance fracture healing or a therapeutic option to treat nonunion, but greater evidences from large volume prospective trials are needed. The Korean Society for Bone and Mineral Research 2020-08 2020-08-31 /pmc/articles/PMC7571240/ /pubmed/32911581 http://dx.doi.org/10.11005/jbm.2020.27.3.167 Text en Copyright © 2020 The Korean Society for Bone and Mineral Research This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yoon, Byung-Ho
Kim, Ki-Choul
Does Teriparatide Improve Fracture Union?: A Systematic Review
title Does Teriparatide Improve Fracture Union?: A Systematic Review
title_full Does Teriparatide Improve Fracture Union?: A Systematic Review
title_fullStr Does Teriparatide Improve Fracture Union?: A Systematic Review
title_full_unstemmed Does Teriparatide Improve Fracture Union?: A Systematic Review
title_short Does Teriparatide Improve Fracture Union?: A Systematic Review
title_sort does teriparatide improve fracture union?: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571240/
https://www.ncbi.nlm.nih.gov/pubmed/32911581
http://dx.doi.org/10.11005/jbm.2020.27.3.167
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