Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial cells, and increasing its expression is a potential treatment for heart failure. Here, we report the design of a small molecule (TGP-377) that specifically and potently enhances VEGFA expression by the targetin...

Descripción completa

Detalles Bibliográficos
Autores principales: Haniff, Hafeez S., Knerr, Laurent, Liu, Xiaohui, Crynen, Gogce, Boström, Jonas, Abegg, Daniel, Adibekian, Alexander, Lekah, Elizabeth, Wang, Kye Won, Cameron, Michael D., Yildirim, Ilyas, Lemurell, Malin, Disney, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571259/
https://www.ncbi.nlm.nih.gov/pubmed/32839603
http://dx.doi.org/10.1038/s41557-020-0514-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571259/
https://www.ncbi.nlm.nih.gov/pubmed/32839603
http://dx.doi.org/10.1038/s41557-020-0514-4

Ejemplares similares