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Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions
Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial cells, and increasing its expression is a potential treatment for heart failure. Here, we report the design of a small molecule (TGP-377) that specifically and potently enhances VEGFA expression by the targetin...
Autores principales: | Haniff, Hafeez S., Knerr, Laurent, Liu, Xiaohui, Crynen, Gogce, Boström, Jonas, Abegg, Daniel, Adibekian, Alexander, Lekah, Elizabeth, Wang, Kye Won, Cameron, Michael D., Yildirim, Ilyas, Lemurell, Malin, Disney, Matthew D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571259/ https://www.ncbi.nlm.nih.gov/pubmed/32839603 http://dx.doi.org/10.1038/s41557-020-0514-4 |
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