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Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study
OBJECTIVE: Inhalational drugs used in treating asthma have several side effects including those on oral tissues. We therefore designed a study to analyze the effects of inhalational drugs on the buccal mucosal cells of the oral cavity. METHODS: Smears were obtained from clinically normal buccal muco...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rambam Health Care Campus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571427/ https://www.ncbi.nlm.nih.gov/pubmed/32441649 http://dx.doi.org/10.5041/RMMJ.10405 |
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author | Benazir, Mohammed Ismail Prasad, Harikrishnan Rajmohan, Muthusamy Srichinthu, Kenniyan Kumar Prema, Perumal Mahalakshmi, Loganathan Kumar, Gopal Shiva |
author_facet | Benazir, Mohammed Ismail Prasad, Harikrishnan Rajmohan, Muthusamy Srichinthu, Kenniyan Kumar Prema, Perumal Mahalakshmi, Loganathan Kumar, Gopal Shiva |
author_sort | Benazir, Mohammed Ismail |
collection | PubMed |
description | OBJECTIVE: Inhalational drugs used in treating asthma have several side effects including those on oral tissues. We therefore designed a study to analyze the effects of inhalational drugs on the buccal mucosal cells of the oral cavity. METHODS: Smears were obtained from clinically normal buccal mucosa of 20 randomly selected asthmatic patients who had been under inhalational therapy for at least 6 months. The Papanicolaou-stained smears were then analyzed for average nuclear area, average cytoplasmic area, and average nuclear area:cytoplasmic area ratio for each patient, and the values were compared with those of 10 healthy controls. RESULTS: A statistically significant decrease in cytoplasmic area (P<0.001) was found in asthmatic patients compared to controls. A significant increase in mean nuclear area:cytoplasmic area ratio (P<0.001) was noted in asthmatic patients when compared to controls. CONCLUSION: Prolonged use of inhalational drugs in patients diagnosed with asthma is associated with changes in oral epithelial cells. There is a need to assess whether these are the direct adverse effects of such drugs and whether they have any long-term impact on oral tissues. |
format | Online Article Text |
id | pubmed-7571427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Rambam Health Care Campus |
record_format | MEDLINE/PubMed |
spelling | pubmed-75714272020-10-30 Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study Benazir, Mohammed Ismail Prasad, Harikrishnan Rajmohan, Muthusamy Srichinthu, Kenniyan Kumar Prema, Perumal Mahalakshmi, Loganathan Kumar, Gopal Shiva Rambam Maimonides Med J Original Research OBJECTIVE: Inhalational drugs used in treating asthma have several side effects including those on oral tissues. We therefore designed a study to analyze the effects of inhalational drugs on the buccal mucosal cells of the oral cavity. METHODS: Smears were obtained from clinically normal buccal mucosa of 20 randomly selected asthmatic patients who had been under inhalational therapy for at least 6 months. The Papanicolaou-stained smears were then analyzed for average nuclear area, average cytoplasmic area, and average nuclear area:cytoplasmic area ratio for each patient, and the values were compared with those of 10 healthy controls. RESULTS: A statistically significant decrease in cytoplasmic area (P<0.001) was found in asthmatic patients compared to controls. A significant increase in mean nuclear area:cytoplasmic area ratio (P<0.001) was noted in asthmatic patients when compared to controls. CONCLUSION: Prolonged use of inhalational drugs in patients diagnosed with asthma is associated with changes in oral epithelial cells. There is a need to assess whether these are the direct adverse effects of such drugs and whether they have any long-term impact on oral tissues. Rambam Health Care Campus 2020-10-14 /pmc/articles/PMC7571427/ /pubmed/32441649 http://dx.doi.org/10.5041/RMMJ.10405 Text en Copyright: © 2020 Benazir et al. This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Benazir, Mohammed Ismail Prasad, Harikrishnan Rajmohan, Muthusamy Srichinthu, Kenniyan Kumar Prema, Perumal Mahalakshmi, Loganathan Kumar, Gopal Shiva Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study |
title | Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study |
title_full | Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study |
title_fullStr | Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study |
title_full_unstemmed | Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study |
title_short | Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study |
title_sort | effect of inhalational therapy on buccal mucosal cells in asthmatic patients: a cytological study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571427/ https://www.ncbi.nlm.nih.gov/pubmed/32441649 http://dx.doi.org/10.5041/RMMJ.10405 |
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