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Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study

OBJECTIVE: Inhalational drugs used in treating asthma have several side effects including those on oral tissues. We therefore designed a study to analyze the effects of inhalational drugs on the buccal mucosal cells of the oral cavity. METHODS: Smears were obtained from clinically normal buccal muco...

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Autores principales: Benazir, Mohammed Ismail, Prasad, Harikrishnan, Rajmohan, Muthusamy, Srichinthu, Kenniyan Kumar, Prema, Perumal, Mahalakshmi, Loganathan, Kumar, Gopal Shiva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rambam Health Care Campus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571427/
https://www.ncbi.nlm.nih.gov/pubmed/32441649
http://dx.doi.org/10.5041/RMMJ.10405
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author Benazir, Mohammed Ismail
Prasad, Harikrishnan
Rajmohan, Muthusamy
Srichinthu, Kenniyan Kumar
Prema, Perumal
Mahalakshmi, Loganathan
Kumar, Gopal Shiva
author_facet Benazir, Mohammed Ismail
Prasad, Harikrishnan
Rajmohan, Muthusamy
Srichinthu, Kenniyan Kumar
Prema, Perumal
Mahalakshmi, Loganathan
Kumar, Gopal Shiva
author_sort Benazir, Mohammed Ismail
collection PubMed
description OBJECTIVE: Inhalational drugs used in treating asthma have several side effects including those on oral tissues. We therefore designed a study to analyze the effects of inhalational drugs on the buccal mucosal cells of the oral cavity. METHODS: Smears were obtained from clinically normal buccal mucosa of 20 randomly selected asthmatic patients who had been under inhalational therapy for at least 6 months. The Papanicolaou-stained smears were then analyzed for average nuclear area, average cytoplasmic area, and average nuclear area:cytoplasmic area ratio for each patient, and the values were compared with those of 10 healthy controls. RESULTS: A statistically significant decrease in cytoplasmic area (P<0.001) was found in asthmatic patients compared to controls. A significant increase in mean nuclear area:cytoplasmic area ratio (P<0.001) was noted in asthmatic patients when compared to controls. CONCLUSION: Prolonged use of inhalational drugs in patients diagnosed with asthma is associated with changes in oral epithelial cells. There is a need to assess whether these are the direct adverse effects of such drugs and whether they have any long-term impact on oral tissues.
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spelling pubmed-75714272020-10-30 Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study Benazir, Mohammed Ismail Prasad, Harikrishnan Rajmohan, Muthusamy Srichinthu, Kenniyan Kumar Prema, Perumal Mahalakshmi, Loganathan Kumar, Gopal Shiva Rambam Maimonides Med J Original Research OBJECTIVE: Inhalational drugs used in treating asthma have several side effects including those on oral tissues. We therefore designed a study to analyze the effects of inhalational drugs on the buccal mucosal cells of the oral cavity. METHODS: Smears were obtained from clinically normal buccal mucosa of 20 randomly selected asthmatic patients who had been under inhalational therapy for at least 6 months. The Papanicolaou-stained smears were then analyzed for average nuclear area, average cytoplasmic area, and average nuclear area:cytoplasmic area ratio for each patient, and the values were compared with those of 10 healthy controls. RESULTS: A statistically significant decrease in cytoplasmic area (P<0.001) was found in asthmatic patients compared to controls. A significant increase in mean nuclear area:cytoplasmic area ratio (P<0.001) was noted in asthmatic patients when compared to controls. CONCLUSION: Prolonged use of inhalational drugs in patients diagnosed with asthma is associated with changes in oral epithelial cells. There is a need to assess whether these are the direct adverse effects of such drugs and whether they have any long-term impact on oral tissues. Rambam Health Care Campus 2020-10-14 /pmc/articles/PMC7571427/ /pubmed/32441649 http://dx.doi.org/10.5041/RMMJ.10405 Text en Copyright: © 2020 Benazir et al. This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Benazir, Mohammed Ismail
Prasad, Harikrishnan
Rajmohan, Muthusamy
Srichinthu, Kenniyan Kumar
Prema, Perumal
Mahalakshmi, Loganathan
Kumar, Gopal Shiva
Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study
title Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study
title_full Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study
title_fullStr Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study
title_full_unstemmed Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study
title_short Effect of Inhalational Therapy on Buccal Mucosal Cells in Asthmatic Patients: A Cytological Study
title_sort effect of inhalational therapy on buccal mucosal cells in asthmatic patients: a cytological study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571427/
https://www.ncbi.nlm.nih.gov/pubmed/32441649
http://dx.doi.org/10.5041/RMMJ.10405
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