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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

Loss of PTEN, the negative regulator of PI3K activity, is frequent in glioblastomas (GBMs). However, the role of the two major PI3K isoforms, p110α and p110β, in PTEN-deficient gliomagenesis remains unknown. We show that PTEN-deficient GBM largely depends on p110α for proliferation and p110β for mig...

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Detalles Bibliográficos
Autores principales:	Xie, Shaozhen, Ni, Jing, McFaline-Figueroa, J. Ricardo, Wang, Yanzhi, Bronson, Roderick T., Ligon, Keith L., Wen, Patrick Y., Roberts, Thomas M., Zhao, Jean J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571617/ https://www.ncbi.nlm.nih.gov/pubmed/32997991 http://dx.doi.org/10.1016/j.celrep.2020.108196

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