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Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana

Although malaria mortality among children under five years of age is high, the characteristics of their infection patterns are not well described. The aim of this study was to examine the longitudinal sequence pattern of Plasmodium falciparum infections in the first year of life within a birth cohor...

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Autores principales: Botwe, Akua Kyerewaa, Owusu-Agyei, Seth, Asghar, Muhammad, Hammar, Ulf, Oppong, Felix Boakye, Gyaase, Stephaney, Dosoo, David, Jakpa, Gabriel, Boamah, Ellen, Twumasi, Mieks Frenken, Osier, Faith, Färnert, Anna, Asante, Kwaku Poku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571695/
https://www.ncbi.nlm.nih.gov/pubmed/33075074
http://dx.doi.org/10.1371/journal.pone.0240814
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author Botwe, Akua Kyerewaa
Owusu-Agyei, Seth
Asghar, Muhammad
Hammar, Ulf
Oppong, Felix Boakye
Gyaase, Stephaney
Dosoo, David
Jakpa, Gabriel
Boamah, Ellen
Twumasi, Mieks Frenken
Osier, Faith
Färnert, Anna
Asante, Kwaku Poku
author_facet Botwe, Akua Kyerewaa
Owusu-Agyei, Seth
Asghar, Muhammad
Hammar, Ulf
Oppong, Felix Boakye
Gyaase, Stephaney
Dosoo, David
Jakpa, Gabriel
Boamah, Ellen
Twumasi, Mieks Frenken
Osier, Faith
Färnert, Anna
Asante, Kwaku Poku
author_sort Botwe, Akua Kyerewaa
collection PubMed
description Although malaria mortality among children under five years of age is high, the characteristics of their infection patterns are not well described. The aim of this study was to examine the longitudinal sequence pattern of Plasmodium falciparum infections in the first year of life within a birth cohort in Kintampo, Ghana (N = 1855). Infants were monitored at home with monthly sampling and also at the clinic for any febrile illness between 2008 and 2011. Light microscopy was performed on monthly scheduled visits and febrile ill visits over twelve months of follow-ups (n = 19231). Microscopy-positive visits accompanied with or without symptoms were rare during the first five months of life but were common from six to twelve months of age. Among 1264 infants with microscopy data over a minimum of eight monthly visits and also throughout in sick visits, some were microscopy negative (36%), and others positive: only-symptomatic (35%), alternating (22%) and only-asymptomatic (7%). The median age of microscopic infection was seven months for the alternating group and eight months for both the only-symptomatic and only-asymptomatic groups. The alternating group had the highest cumulative incidence of microscopic infections, the lowest age at first infection and 87 different infection patterns. Parasite densities detected by microscopy were significantly higher for symptomatic versus asymptomatic infection. We conclude that infants in malaria endemic areas experience diverse infection profiles throughout their first year of life. Further investigations should include submicroscopic reservoir and may shed more light on the factors that determine susceptibility to malaria during infancy.
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spelling pubmed-75716952020-10-26 Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana Botwe, Akua Kyerewaa Owusu-Agyei, Seth Asghar, Muhammad Hammar, Ulf Oppong, Felix Boakye Gyaase, Stephaney Dosoo, David Jakpa, Gabriel Boamah, Ellen Twumasi, Mieks Frenken Osier, Faith Färnert, Anna Asante, Kwaku Poku PLoS One Research Article Although malaria mortality among children under five years of age is high, the characteristics of their infection patterns are not well described. The aim of this study was to examine the longitudinal sequence pattern of Plasmodium falciparum infections in the first year of life within a birth cohort in Kintampo, Ghana (N = 1855). Infants were monitored at home with monthly sampling and also at the clinic for any febrile illness between 2008 and 2011. Light microscopy was performed on monthly scheduled visits and febrile ill visits over twelve months of follow-ups (n = 19231). Microscopy-positive visits accompanied with or without symptoms were rare during the first five months of life but were common from six to twelve months of age. Among 1264 infants with microscopy data over a minimum of eight monthly visits and also throughout in sick visits, some were microscopy negative (36%), and others positive: only-symptomatic (35%), alternating (22%) and only-asymptomatic (7%). The median age of microscopic infection was seven months for the alternating group and eight months for both the only-symptomatic and only-asymptomatic groups. The alternating group had the highest cumulative incidence of microscopic infections, the lowest age at first infection and 87 different infection patterns. Parasite densities detected by microscopy were significantly higher for symptomatic versus asymptomatic infection. We conclude that infants in malaria endemic areas experience diverse infection profiles throughout their first year of life. Further investigations should include submicroscopic reservoir and may shed more light on the factors that determine susceptibility to malaria during infancy. Public Library of Science 2020-10-19 /pmc/articles/PMC7571695/ /pubmed/33075074 http://dx.doi.org/10.1371/journal.pone.0240814 Text en © 2020 Botwe et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Botwe, Akua Kyerewaa
Owusu-Agyei, Seth
Asghar, Muhammad
Hammar, Ulf
Oppong, Felix Boakye
Gyaase, Stephaney
Dosoo, David
Jakpa, Gabriel
Boamah, Ellen
Twumasi, Mieks Frenken
Osier, Faith
Färnert, Anna
Asante, Kwaku Poku
Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana
title Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana
title_full Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana
title_fullStr Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana
title_full_unstemmed Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana
title_short Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana
title_sort profiles of plasmodium falciparum infections detected by microscopy through the first year of life in kintampo a high transmission area of ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571695/
https://www.ncbi.nlm.nih.gov/pubmed/33075074
http://dx.doi.org/10.1371/journal.pone.0240814
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