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Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana
Although malaria mortality among children under five years of age is high, the characteristics of their infection patterns are not well described. The aim of this study was to examine the longitudinal sequence pattern of Plasmodium falciparum infections in the first year of life within a birth cohor...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571695/ https://www.ncbi.nlm.nih.gov/pubmed/33075074 http://dx.doi.org/10.1371/journal.pone.0240814 |
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author | Botwe, Akua Kyerewaa Owusu-Agyei, Seth Asghar, Muhammad Hammar, Ulf Oppong, Felix Boakye Gyaase, Stephaney Dosoo, David Jakpa, Gabriel Boamah, Ellen Twumasi, Mieks Frenken Osier, Faith Färnert, Anna Asante, Kwaku Poku |
author_facet | Botwe, Akua Kyerewaa Owusu-Agyei, Seth Asghar, Muhammad Hammar, Ulf Oppong, Felix Boakye Gyaase, Stephaney Dosoo, David Jakpa, Gabriel Boamah, Ellen Twumasi, Mieks Frenken Osier, Faith Färnert, Anna Asante, Kwaku Poku |
author_sort | Botwe, Akua Kyerewaa |
collection | PubMed |
description | Although malaria mortality among children under five years of age is high, the characteristics of their infection patterns are not well described. The aim of this study was to examine the longitudinal sequence pattern of Plasmodium falciparum infections in the first year of life within a birth cohort in Kintampo, Ghana (N = 1855). Infants were monitored at home with monthly sampling and also at the clinic for any febrile illness between 2008 and 2011. Light microscopy was performed on monthly scheduled visits and febrile ill visits over twelve months of follow-ups (n = 19231). Microscopy-positive visits accompanied with or without symptoms were rare during the first five months of life but were common from six to twelve months of age. Among 1264 infants with microscopy data over a minimum of eight monthly visits and also throughout in sick visits, some were microscopy negative (36%), and others positive: only-symptomatic (35%), alternating (22%) and only-asymptomatic (7%). The median age of microscopic infection was seven months for the alternating group and eight months for both the only-symptomatic and only-asymptomatic groups. The alternating group had the highest cumulative incidence of microscopic infections, the lowest age at first infection and 87 different infection patterns. Parasite densities detected by microscopy were significantly higher for symptomatic versus asymptomatic infection. We conclude that infants in malaria endemic areas experience diverse infection profiles throughout their first year of life. Further investigations should include submicroscopic reservoir and may shed more light on the factors that determine susceptibility to malaria during infancy. |
format | Online Article Text |
id | pubmed-7571695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75716952020-10-26 Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana Botwe, Akua Kyerewaa Owusu-Agyei, Seth Asghar, Muhammad Hammar, Ulf Oppong, Felix Boakye Gyaase, Stephaney Dosoo, David Jakpa, Gabriel Boamah, Ellen Twumasi, Mieks Frenken Osier, Faith Färnert, Anna Asante, Kwaku Poku PLoS One Research Article Although malaria mortality among children under five years of age is high, the characteristics of their infection patterns are not well described. The aim of this study was to examine the longitudinal sequence pattern of Plasmodium falciparum infections in the first year of life within a birth cohort in Kintampo, Ghana (N = 1855). Infants were monitored at home with monthly sampling and also at the clinic for any febrile illness between 2008 and 2011. Light microscopy was performed on monthly scheduled visits and febrile ill visits over twelve months of follow-ups (n = 19231). Microscopy-positive visits accompanied with or without symptoms were rare during the first five months of life but were common from six to twelve months of age. Among 1264 infants with microscopy data over a minimum of eight monthly visits and also throughout in sick visits, some were microscopy negative (36%), and others positive: only-symptomatic (35%), alternating (22%) and only-asymptomatic (7%). The median age of microscopic infection was seven months for the alternating group and eight months for both the only-symptomatic and only-asymptomatic groups. The alternating group had the highest cumulative incidence of microscopic infections, the lowest age at first infection and 87 different infection patterns. Parasite densities detected by microscopy were significantly higher for symptomatic versus asymptomatic infection. We conclude that infants in malaria endemic areas experience diverse infection profiles throughout their first year of life. Further investigations should include submicroscopic reservoir and may shed more light on the factors that determine susceptibility to malaria during infancy. Public Library of Science 2020-10-19 /pmc/articles/PMC7571695/ /pubmed/33075074 http://dx.doi.org/10.1371/journal.pone.0240814 Text en © 2020 Botwe et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Botwe, Akua Kyerewaa Owusu-Agyei, Seth Asghar, Muhammad Hammar, Ulf Oppong, Felix Boakye Gyaase, Stephaney Dosoo, David Jakpa, Gabriel Boamah, Ellen Twumasi, Mieks Frenken Osier, Faith Färnert, Anna Asante, Kwaku Poku Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana |
title | Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana |
title_full | Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana |
title_fullStr | Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana |
title_full_unstemmed | Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana |
title_short | Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana |
title_sort | profiles of plasmodium falciparum infections detected by microscopy through the first year of life in kintampo a high transmission area of ghana |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571695/ https://www.ncbi.nlm.nih.gov/pubmed/33075074 http://dx.doi.org/10.1371/journal.pone.0240814 |
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