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Mutation bias interacts with composition bias to influence adaptive evolution
Mutation is a biased stochastic process, with some types of mutations occurring more frequently than others. Previous work has used synthetic genotype-phenotype landscapes to study how such mutation bias affects adaptive evolution. Here, we consider 746 empirical genotype-phenotype landscapes, each...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571706/ https://www.ncbi.nlm.nih.gov/pubmed/32986712 http://dx.doi.org/10.1371/journal.pcbi.1008296 |
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author | Cano, Alejandro V. Payne, Joshua L. |
author_facet | Cano, Alejandro V. Payne, Joshua L. |
author_sort | Cano, Alejandro V. |
collection | PubMed |
description | Mutation is a biased stochastic process, with some types of mutations occurring more frequently than others. Previous work has used synthetic genotype-phenotype landscapes to study how such mutation bias affects adaptive evolution. Here, we consider 746 empirical genotype-phenotype landscapes, each of which describes the binding affinity of target DNA sequences to a transcription factor, to study the influence of mutation bias on adaptive evolution of increased binding affinity. By using empirical genotype-phenotype landscapes, we need to make only few assumptions about landscape topography and about the DNA sequences that each landscape contains. The latter is particularly important because the set of sequences that a landscape contains determines the types of mutations that can occur along a mutational path to an adaptive peak. That is, landscapes can exhibit a composition bias—a statistical enrichment of a particular type of mutation relative to a null expectation, throughout an entire landscape or along particular mutational paths—that is independent of any bias in the mutation process. Our results reveal the way in which composition bias interacts with biases in the mutation process under different population genetic conditions, and how such interaction impacts fundamental properties of adaptive evolution, such as its predictability, as well as the evolution of genetic diversity and mutational robustness. |
format | Online Article Text |
id | pubmed-7571706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75717062020-10-26 Mutation bias interacts with composition bias to influence adaptive evolution Cano, Alejandro V. Payne, Joshua L. PLoS Comput Biol Research Article Mutation is a biased stochastic process, with some types of mutations occurring more frequently than others. Previous work has used synthetic genotype-phenotype landscapes to study how such mutation bias affects adaptive evolution. Here, we consider 746 empirical genotype-phenotype landscapes, each of which describes the binding affinity of target DNA sequences to a transcription factor, to study the influence of mutation bias on adaptive evolution of increased binding affinity. By using empirical genotype-phenotype landscapes, we need to make only few assumptions about landscape topography and about the DNA sequences that each landscape contains. The latter is particularly important because the set of sequences that a landscape contains determines the types of mutations that can occur along a mutational path to an adaptive peak. That is, landscapes can exhibit a composition bias—a statistical enrichment of a particular type of mutation relative to a null expectation, throughout an entire landscape or along particular mutational paths—that is independent of any bias in the mutation process. Our results reveal the way in which composition bias interacts with biases in the mutation process under different population genetic conditions, and how such interaction impacts fundamental properties of adaptive evolution, such as its predictability, as well as the evolution of genetic diversity and mutational robustness. Public Library of Science 2020-09-28 /pmc/articles/PMC7571706/ /pubmed/32986712 http://dx.doi.org/10.1371/journal.pcbi.1008296 Text en © 2020 Cano, Payne http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Cano, Alejandro V. Payne, Joshua L. Mutation bias interacts with composition bias to influence adaptive evolution |
title | Mutation bias interacts with composition bias to influence adaptive evolution |
title_full | Mutation bias interacts with composition bias to influence adaptive evolution |
title_fullStr | Mutation bias interacts with composition bias to influence adaptive evolution |
title_full_unstemmed | Mutation bias interacts with composition bias to influence adaptive evolution |
title_short | Mutation bias interacts with composition bias to influence adaptive evolution |
title_sort | mutation bias interacts with composition bias to influence adaptive evolution |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571706/ https://www.ncbi.nlm.nih.gov/pubmed/32986712 http://dx.doi.org/10.1371/journal.pcbi.1008296 |
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