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Heterogeneity of dengue transmission in an endemic area of Colombia

Population based serological surveys are the gold-standard to quantify dengue (DENV) transmission. The purpose of this study was to estimate the age-specific seroprevalence and the force of infection of DENV in an endemic area of Colombia. Between July and October 2014, we conducted a household base...

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Autores principales: Estupiñán Cárdenas, María Isabel, Herrera, Víctor Mauricio, Miranda Montoya, María Consuelo, Lozano Parra, Anyela, Zaraza Moncayo, Zuly Milena, Flórez García, Janeth Patricia, Rodríguez Barraquer, Isabel, Villar Centeno, Luis Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571714/
https://www.ncbi.nlm.nih.gov/pubmed/32925978
http://dx.doi.org/10.1371/journal.pntd.0008122
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author Estupiñán Cárdenas, María Isabel
Herrera, Víctor Mauricio
Miranda Montoya, María Consuelo
Lozano Parra, Anyela
Zaraza Moncayo, Zuly Milena
Flórez García, Janeth Patricia
Rodríguez Barraquer, Isabel
Villar Centeno, Luis Ángel
author_facet Estupiñán Cárdenas, María Isabel
Herrera, Víctor Mauricio
Miranda Montoya, María Consuelo
Lozano Parra, Anyela
Zaraza Moncayo, Zuly Milena
Flórez García, Janeth Patricia
Rodríguez Barraquer, Isabel
Villar Centeno, Luis Ángel
author_sort Estupiñán Cárdenas, María Isabel
collection PubMed
description Population based serological surveys are the gold-standard to quantify dengue (DENV) transmission. The purpose of this study was to estimate the age-specific seroprevalence and the force of infection of DENV in an endemic area of Colombia. Between July and October 2014, we conducted a household based cross-sectional survey among 1.037 individuals aged 2 to 40 years living in 40 randomly selected locations in urban Piedecuesta, Santander, Colombia. In addition, we also enrolled 246 indviduals living in rural “veredas”. Participants were asked to answer a questionnaire that included demographic, socioeconomic and environmental questions and to provide a 5 ml blood sample. Sera were tested using the IgG indirect ELISA (Panbio) kit to determine past DENV infection. The overall DENV seroprevalence was 70% (95% CI = 67%-71%), but was significantly higher in urban (81%, 95% CI = 78%-83%) as compared to rural (21%, 95% CI = 17%-27%) locations. Age was a major predictor of seropositivity, consistent with endemic circulation of the virus. Using catalytic models we estimated that on average, 12% (95%CI = 11%-13%) of susceptible individuals living in the city are infected by DENV each year. Beyond age, the only predictor of seropositivity in urban locations was prior history of dengue diagnosed by a physician (aPR 1.15, 95% CI = 0.98–1.35). Among participants living in rural settings, those that reported traveling outside of their vereda were more likely to be seropositive (aPR 3.60, 95%CI = 1.54–8.42) as well as those who were born outside of Santander department (aPR = 2.77, 95%CI = 1.20–6.37). These results are consistent with long term endemic circulation of DENV in Piedecuesta, with large heterogeneities between urban and rural areas located just a few kilometers apart. Design of DENV control interventions, including vaccination, will need to consider this fine scale spatial heterogeneity.
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spelling pubmed-75717142020-10-26 Heterogeneity of dengue transmission in an endemic area of Colombia Estupiñán Cárdenas, María Isabel Herrera, Víctor Mauricio Miranda Montoya, María Consuelo Lozano Parra, Anyela Zaraza Moncayo, Zuly Milena Flórez García, Janeth Patricia Rodríguez Barraquer, Isabel Villar Centeno, Luis Ángel PLoS Negl Trop Dis Research Article Population based serological surveys are the gold-standard to quantify dengue (DENV) transmission. The purpose of this study was to estimate the age-specific seroprevalence and the force of infection of DENV in an endemic area of Colombia. Between July and October 2014, we conducted a household based cross-sectional survey among 1.037 individuals aged 2 to 40 years living in 40 randomly selected locations in urban Piedecuesta, Santander, Colombia. In addition, we also enrolled 246 indviduals living in rural “veredas”. Participants were asked to answer a questionnaire that included demographic, socioeconomic and environmental questions and to provide a 5 ml blood sample. Sera were tested using the IgG indirect ELISA (Panbio) kit to determine past DENV infection. The overall DENV seroprevalence was 70% (95% CI = 67%-71%), but was significantly higher in urban (81%, 95% CI = 78%-83%) as compared to rural (21%, 95% CI = 17%-27%) locations. Age was a major predictor of seropositivity, consistent with endemic circulation of the virus. Using catalytic models we estimated that on average, 12% (95%CI = 11%-13%) of susceptible individuals living in the city are infected by DENV each year. Beyond age, the only predictor of seropositivity in urban locations was prior history of dengue diagnosed by a physician (aPR 1.15, 95% CI = 0.98–1.35). Among participants living in rural settings, those that reported traveling outside of their vereda were more likely to be seropositive (aPR 3.60, 95%CI = 1.54–8.42) as well as those who were born outside of Santander department (aPR = 2.77, 95%CI = 1.20–6.37). These results are consistent with long term endemic circulation of DENV in Piedecuesta, with large heterogeneities between urban and rural areas located just a few kilometers apart. Design of DENV control interventions, including vaccination, will need to consider this fine scale spatial heterogeneity. Public Library of Science 2020-09-14 /pmc/articles/PMC7571714/ /pubmed/32925978 http://dx.doi.org/10.1371/journal.pntd.0008122 Text en © 2020 Estupiñán Cárdenas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Estupiñán Cárdenas, María Isabel
Herrera, Víctor Mauricio
Miranda Montoya, María Consuelo
Lozano Parra, Anyela
Zaraza Moncayo, Zuly Milena
Flórez García, Janeth Patricia
Rodríguez Barraquer, Isabel
Villar Centeno, Luis Ángel
Heterogeneity of dengue transmission in an endemic area of Colombia
title Heterogeneity of dengue transmission in an endemic area of Colombia
title_full Heterogeneity of dengue transmission in an endemic area of Colombia
title_fullStr Heterogeneity of dengue transmission in an endemic area of Colombia
title_full_unstemmed Heterogeneity of dengue transmission in an endemic area of Colombia
title_short Heterogeneity of dengue transmission in an endemic area of Colombia
title_sort heterogeneity of dengue transmission in an endemic area of colombia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571714/
https://www.ncbi.nlm.nih.gov/pubmed/32925978
http://dx.doi.org/10.1371/journal.pntd.0008122
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