Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition

PAR (protease-activated receptor)-4 antagonism has antiplatelet effects under conditions of high shear stress. We aimed to establish whether PAR4 antagonism had additive antithrombotic activity in the presence of factor Xa inhibition in an ex vivo model of acute arterial injury. APPROACH AND RESULTS...

Descripción completa

Detalles Bibliográficos
Autores principales: Meah, Mohammed N., Raftis, Jennifer, Wilson, Simon J., Perera, Vidya, Garonzik, Samira M., Murthy, Bindu, Everlof, J. Gerry, Aronson, Ronald, Luettgen, Joseph, Newby, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Translational Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571844/
https://www.ncbi.nlm.nih.gov/pubmed/32907366
http://dx.doi.org/10.1161/ATVBAHA.120.314960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571844/
https://www.ncbi.nlm.nih.gov/pubmed/32907366
http://dx.doi.org/10.1161/ATVBAHA.120.314960

Ejemplares similares