COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions

The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome...

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Detalles Bibliográficos
Autores principales: Brosnahan, Shari B., Jonkman, Annemijn H., Kugler, Matthias C., Munger, John S., Kaufman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Brief Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571846/
https://www.ncbi.nlm.nih.gov/pubmed/32960072
http://dx.doi.org/10.1161/ATVBAHA.120.314515
Descripción
Sumario:The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions. GRAPHIC ABSTRACT: A graphic abstract is available for this article.

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