COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions

The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome...

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Autores principales: Brosnahan, Shari B., Jonkman, Annemijn H., Kugler, Matthias C., Munger, John S., Kaufman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Brief Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571846/
https://www.ncbi.nlm.nih.gov/pubmed/32960072
http://dx.doi.org/10.1161/ATVBAHA.120.314515
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author Brosnahan, Shari B.
Jonkman, Annemijn H.
Kugler, Matthias C.
Munger, John S.
Kaufman, David A.
author_facet Brosnahan, Shari B.
Jonkman, Annemijn H.
Kugler, Matthias C.
Munger, John S.
Kaufman, David A.
author_sort Brosnahan, Shari B.
collection PubMed
description The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions. GRAPHIC ABSTRACT: A graphic abstract is available for this article.
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spelling pubmed-75718462020-10-29 COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions Brosnahan, Shari B. Jonkman, Annemijn H. Kugler, Matthias C. Munger, John S. Kaufman, David A. Arterioscler Thromb Vasc Biol Brief Reviews The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions. GRAPHIC ABSTRACT: A graphic abstract is available for this article. Lippincott Williams & Wilkins 2020-09-22 2020-11 /pmc/articles/PMC7571846/ /pubmed/32960072 http://dx.doi.org/10.1161/ATVBAHA.120.314515 Text en © 2020 The Authors. Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Brief Reviews
Brosnahan, Shari B.
Jonkman, Annemijn H.
Kugler, Matthias C.
Munger, John S.
Kaufman, David A.
COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions
title COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions
title_full COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions
title_fullStr COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions
title_full_unstemmed COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions
title_short COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions
title_sort covid-19 and respiratory system disorders: current knowledge, future clinical and translational research questions
topic Brief Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571846/
https://www.ncbi.nlm.nih.gov/pubmed/32960072
http://dx.doi.org/10.1161/ATVBAHA.120.314515
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